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Tryptic Digestion

Known as: Trypsin Digestion 
A technique for proteolysis of proteins into peptides at lysine or arginine by treatment with the pancreatic enzyme trypsin.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
RATIONALE Pathological angiogenesis is a critical component of diseases, such as ocular disorders, cancers, and atherosclerosis… Expand
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE Vascular endothelial growth factor (VEGF-A or VEGF) is a major pathogenic factor and therapeutic target for diabetic… Expand
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Highly Cited
2008
Highly Cited
2008
We have developed a new protocol for digesting hydrophobic proteins using trypsin with the aid of phase-transfer surfactants (PTS… Expand
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Highly Cited
2008
Highly Cited
2008
Because accumulation of alpha-synuclein (alphaS) in the brain is a hallmark of Parkinson disease (PD) and related disorders, we… Expand
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Highly Cited
2007
Highly Cited
2007
The Paragon™ Algorithm, a novel database search engine for the identification of peptides from tandem mass spectrometry data, is… Expand
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Highly Cited
2003
Highly Cited
2003
Improved in-solution tryptic digestion of proteins in terms of speed and peptide coverage was achieved with the aid of a novel… Expand
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Highly Cited
1996
Highly Cited
1996
The function of many of the uncharacterized open reading frames discovered by genomic sequencing can be determined at the level… Expand
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Highly Cited
1996
Highly Cited
1996
The possible relationship of selenium to immunological function which has been suggested for decades was investigated in studies… Expand
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Highly Cited
1980
Highly Cited
1980
On the basis of their primary structure, the lysine-rich histones are a unified family of proteins. Each has an amino acid chain… Expand
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Highly Cited
1977
Highly Cited
1977
Preparation of small vertebrates cleared after alcian blue staining of cartilage is facilitated by trypsin digestion. Specimens… Expand
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