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Tryptic Digestion

Known as: Trypsin Digestion 
A technique for proteolysis of proteins into peptides at lysine or arginine by treatment with the pancreatic enzyme trypsin.
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Ubiquitination is a post-translational modification (PTM) that is essential for balancing numerous physiological processes. To… 
Highly Cited
2007
Highly Cited
2007
Identification of proteins directly from tissue: in situ tryptic digestions coupled with imaging mass spectrometry.
A novel method for on-tissue identification of proteins in spatially discrete regions is described using tryptic digestion… 
Highly Cited
2005
Highly Cited
2005
Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate.
Hoki (Johnius belengerii) skin gelatin was hydrolyzed with three commercial enzymes to identify radical-scavenging potencies of… 
Highly Cited
1998
Highly Cited
1998
Modification of cysteine residues by alkylation. A tool in peptide mapping and protein identification.
Although mass spectrometric peptide mapping has become an established technique for the rapid identification of proteins isolated… 
Highly Cited
1996
Highly Cited
1996
Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.
The possible relationship of selenium to immunological function which has been suggested for decades was investigated in studies… 
Highly Cited
1986
Highly Cited
1986
Reversible staining and peptide mapping of proteins transferred to nitrocellulose after separation by sodium dodecylsulfate-polyacrylamide gel electrophoresis.
Highly Cited
1984
Highly Cited
1984
C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.
Highly Cited
1980
Highly Cited
1980
The structure of histone H1 and its location in chromatin
On the basis of their primary structure, the lysine-rich histones are a unified family of proteins. Each has an amino acid chain… 
Highly Cited
1978
Highly Cited
1978
Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3': 5'-monophosphate-dependent protein kinase.
Highly Cited
1977
Highly Cited
1977
Structure of a molluscan cardioexcitatory neuropeptide.
A cardioexcitatory substance from ganglia of the clam Macrocallista nimbosa, formerly designated peak C, is the tetrapeptide… 
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