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Trough Concentration

Known as: Conc Trough, Ctrough 
Concentration at end of dosing interval.
National Institutes of Health

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CDISC SDTM Pharmacokinetic Parameter Long Name TerminologyClinical Data Interchange Standards Consortium Terminology

Papers overview

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2019
2019
Strategy for the Prediction of Steady-State Exposure of Digoxin to Determine Drug–Drug Interaction Potential of Digoxin With Other Drugs in Digitalization Therapy
Digoxin, a narrow therapeutic index drug, is widely used in congestive heart failure. However, the digitalization therapy… 
2016
2016
‘Lower anti-drug antibodies with etanercept biosimilar: can Ctrough explain the differences?’
I read with great interest Emery et al 's1 article on SB4 phase III study and subsequent response to comments from Meacci et al… 
2016
2016
Vancomycin Pharmacokinetic Parameters in Patients with Hemorrhagic Stroke
BackgroundInfections are a common medical complication in hemorrhagic stroke patients, with vancomycin commonly used as empiric… 
2016
2016
Higher Trough Concentrations of Infliximab are Associated with Clinical Remission and Mucosal Healing in Patients with Inflammatory Bowel Disease
Objective: Few studies have correlated the infliximab (IFX) trough concentration, clinical remission (CM) and mucosal healing (MH… 
2016
2016
Multiple dose Pharmakokinetik und Metabolismus von Erlotnib in Phase 1b klinischer Prüfung
In der vorliegenden Dissertation wurde, im Rahmen des therapeutischen Drug Monitorings (TDM), die Pharmakokinetik von Erlotinib… 
2015
2015
Bevacizumab Trough Concentration in Recurrent Glioblastoma Patients
Purpose: Predictive marker of bevacizumab activity is an unmet medical need. Our objective was to evaluate the trough… 
2015
2015
Low-Dose Ritonavir-Boosted Atazanavir (200/100 mg) Maintained a High Virological Efficacy Up To 4 Years in Treatment-Experienced HIV-1 Infected Adults: A Prospective Cohort Study from Asia
Background: HIV requires lifelong treatment so ARV dose optimization is important for long-term efficacy and safety. Previously… 
2015
2015
Vancomycin Pharmacokinetic Parameters in Patients with Acute Brain Injury Undergoing Controlled Normothermia, Therapeutic Hypothermia, or Pentobarbital Infusion
BackgroundTherapeutic strategies that cause an alteration in patient temperature, such as controlled normothermia (CN… 
2013
2013
Compartmental pharmacokinetic modeling of lopinavir in humans
Background: Lopinavir is a highly potent protease inhibitors commonly used in treatment of HIV infection. The drug has a very low… 
2006
2006
Human herpes virus-6 encephalitis in a paediatric bone marrow recipient: successful treatment with pharmacokinetic monitoring and high doses of ganciclovir
Human herpes virus-6 encephalitis in a paediatric bone marrow recipient: successful treatment with pharmacokinetic monitoring and…