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Triptolide Analog
A water soluble analog of the diterpenoid triepoxide triptolide isolated from the Chinese herb Tripterygium wilfordii Hook.f., with potential…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
[Effects of Tripterygium Glycosides Tablets from 6 different manufacturers on acute liver injury of normal mice].
Chunfang Liu
,
Jingxuan Zhang
,
+9 authors
N. Lin
Zhongguo Zhong yao za zhi = Zhongguo zhongyao…
2019
Corpus ID: 204243884
The aim of this paper was to compare the performance of acute liver injury in mice induced by Tripterygium Glycosides Tablets…
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2018
2018
Further Study of Influence of Panax notoginseng on Intestinal Absorption Characteristics of Triptolide and Tripterine in Rats with Tripterygium wilfordii
Yiqun Li
,
Benyong Zhang
,
+7 authors
Q. Zhang
Pharmacognosy magazine
2018
Corpus ID: 4207934
Background: Tripterygium wilfordii (TW) is widely employed to treat rheumatoid arthritis and autoimmune disorders clinically…
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2017
2017
Protective Effect of 18β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats
G. Yang
,
L. Wang
,
+9 authors
Haiming Chen
Evidence-based complementary and alternative…
2017
Corpus ID: 25368886
Triptolide (TP) is the major active component of Tripterygium wilfordii Hook F (TWHF) and possesses multiple pharmacological…
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2014
2014
Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102
J. Fidler
,
J. An
,
B. Carter
,
M. Andreeff
Cancer Chemotherapy and Pharmacology
2014
Corpus ID: 20688553
AbstractPurpose Triptolide induces cancer cell apoptosis by inhibiting RNA synthesis and signaling pathways like NF-κB. We…
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2014
2014
Abstract 5110: The role triptolide in sensitizing lung tumor cells to cisplatin-induced apoptosis
G. Wang
,
X. Xu
,
Yi Zhang
2014
Corpus ID: 71950877
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Cisplatin is an anticancer drug used in treatment for many…
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2012
2012
Gender-related Differences in Pharmacokinetics of Novel Prodrug of Triptolide MC002 in Rats
Liu Ping-xia
2012
Corpus ID: 100473846
Objective To investigate Gender-related differences in the pharmacokinetics of MC002,a novel prodrug of triptolide.Methods MC002…
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Review
2012
Review
2012
Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8)
W. Tang
,
Jian-ping Zuo
Acta Pharmacologica Sinica
2012
Corpus ID: 16693607
The Chinese traditional herb Tripterygium wilfordii Hook f (TwHF) has been widely used in the treatment of autoimmune and…
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2011
2011
CANADIAN SOCIETY OF TRANSPLANTATION SOCIÉTÉ CANADIENNE DE TRANSPLANTATION ANNUAL SCIENTIFIC MEETING RÉUNION SCIENTIFIQUE ANNUELLE
K. Tinckam
,
D. Kumar
2011
Corpus ID: 46966475
The composite tissue allotransplantations (CTA) are not routinely performed for tissue reconstruction due to the potentially…
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2009
2009
Triptolide abrogates oncogene FIP1L1‐PDGFRα addiction and induces apoptosis in hypereosinophilic syndrome
Y. Jin
,
Qi Chen
,
Zhongzheng Lu
,
B. Chen
,
J. Pan
Cancer science
2009
Corpus ID: 2371773
The pathogenesis of hypereosinophilic syndrome (HES) in some patients is highly dependent on FIP1‐Like‐1 (FIP1L1)–platelet…
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Highly Cited
2005
Highly Cited
2005
(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo.
Ru Zhou
,
F. Zhang
,
+9 authors
Jian-ping Zuo
International immunopharmacology
2005
Corpus ID: 26041761
A series of triptolide analogs have been successfully synthesized. In the present study we demonstrated one of them, (5R)-5…
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