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Triptolide Analog

A water soluble analog of the diterpenoid triepoxide triptolide isolated from the Chinese herb Tripterygium wilfordii Hook.f., with potential… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
[Effects of Tripterygium Glycosides Tablets from 6 different manufacturers on acute liver injury of normal mice].
The aim of this paper was to compare the performance of acute liver injury in mice induced by Tripterygium Glycosides Tablets… 
2018
2018
Further Study of Influence of Panax notoginseng on Intestinal Absorption Characteristics of Triptolide and Tripterine in Rats with Tripterygium wilfordii
Background: Tripterygium wilfordii (TW) is widely employed to treat rheumatoid arthritis and autoimmune disorders clinically… 
2017
2017
Protective Effect of 18β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats
Triptolide (TP) is the major active component of Tripterygium wilfordii Hook F (TWHF) and possesses multiple pharmacological… 
2014
2014
Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102
AbstractPurpose Triptolide induces cancer cell apoptosis by inhibiting RNA synthesis and signaling pathways like NF-κB. We… 
2014
2014
Abstract 5110: The role triptolide in sensitizing lung tumor cells to cisplatin-induced apoptosis
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Cisplatin is an anticancer drug used in treatment for many… 
Review
2012
Review
2012
Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8)
The Chinese traditional herb Tripterygium wilfordii Hook f (TwHF) has been widely used in the treatment of autoimmune and… 
2012
2012
Gender-related Differences in Pharmacokinetics of Novel Prodrug of Triptolide MC002 in Rats
Objective To investigate Gender-related differences in the pharmacokinetics of MC002,a novel prodrug of triptolide.Methods MC002… 
2011
2011
CANADIAN SOCIETY OF TRANSPLANTATION SOCIÉTÉ CANADIENNE DE TRANSPLANTATION ANNUAL SCIENTIFIC MEETING RÉUNION SCIENTIFIQUE ANNUELLE
The composite tissue allotransplantations (CTA) are not routinely performed for tissue reconstruction due to the potentially… 
2009
2009
Triptolide abrogates oncogene FIP1L1‐PDGFRα addiction and induces apoptosis in hypereosinophilic syndrome
The pathogenesis of hypereosinophilic syndrome (HES) in some patients is highly dependent on FIP1‐Like‐1 (FIP1L1)–platelet… 
Highly Cited
2005
Highly Cited
2005
(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo.
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