Trimetazidine

Known as: 1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride, Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, Trimetazidine [Chemical/Ingredient] 
A vasodilator used in angina of effort or ischemic heart disease.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND The anti-ischemic agent trimetazidine improves ejection fraction in heart failure that is hypothetically linked to… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVES This study sought to assess whether the long-term addition of trimetazidine to conventional treatment could improve… (More)
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Highly Cited
2006
Highly Cited
2006
AIMS The addition of trimetazidine to standard treatment has been shown to improve left ventricular (LV) function in patients… (More)
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Highly Cited
2004
Highly Cited
2004
AIM Elderly patients have an increased incidence of ischaemic dilated cardiomyopathy often related to diffuse coronary artery… (More)
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Highly Cited
2003
Highly Cited
2003
High rates of fatty acid oxidation in the heart and subsequent inhibition of glucose oxidation contributes to the severity of… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Patients with diabetic cardiomyopathy have an impaired myocardial glucose handling and distal distribution of coronary… (More)
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Highly Cited
2001
Highly Cited
2001
AIMS To assess the antiischaemic efficacy and tolerability of the metabolic agent trimetazidine in combination with metoprolol in… (More)
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Highly Cited
2000
Highly Cited
2000
Trimetazidine is a clinically effective antianginal agent that has no negative inotropic or vasodilator properties. Although it… (More)
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Review
1997
Review
1997
It is now clear that the availability of different metabolic substrates can have a profound influence on the extent of damage… (More)
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Highly Cited
1994
Highly Cited
1994
1. Trimetazidine has a direct anti-ischaemic effect on the myocardium without altering the rate x pressure product or coronary… (More)
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