FAQ

Tolperisone

Known as: 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, Tolperisone [Chemical/Ingredient] 
A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra… (More)

Topic mentions per year

Topic mentions per year

1976-2017
0246819762017

Related topics

Related topics

12 relations
In BloodTolperisone Hydrochlorideadministration & dosageagonists
(More)

Broader (1)

Muscle Relaxants, Central

Narrower (2)

MydetonMydocalm

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Tolperisone
agonists
chemical synthesis
standards characteristics
Mydocalm
Muscle Relaxants, Central

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Considerable interindividual variation in the pharmacokinetics of tolperisone HCl.
OBJECTIVE The aim of this study was to determine the pharmacokinetic profiles of oral tolperisone hydrochloride in healthy… (More)
Is this relevant?
2006
2006
HPLC determination of tolperisone in human plasma.
A simple high performance liquid chromatographic (HPLC) method was developed for the determination of tolperisone in human plasma… (More)
Is this relevant?
2006
2006
A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms.
The specific, acute interaction of tolperisone, an agent used as a muscle relaxant and for the treatment of chronic pain… (More)
Is this relevant?
2005
2005
Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels.
The spinal reflex depressant mechanism of tolperisone and some of its structural analogs with central muscle relaxant action was… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2003
2003
Anaphylactic reactions to tolperisone (Mydocalm).
Four patients with anaphylaxis attributed to the intake of the centrally acting muscle relaxant tolperisone hydrochloride… (More)
Is this relevant?
2003
2003
Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.
The in vitro metabolism of tolperisone, 1-(4-methyl-phenyl)-2-methyl-3-(1-piperidino)-1-propanone-hydrochloride, a centrally… (More)
  • table 2
  • table 1
  • figure 1
  • table 3
  • figure 2
Is this relevant?
2001
2001
Simultaneous determination of tolperisone and lidocaine by high performance liquid chromatography.
A reversed phase high performance liquid chromatographic (RP-HPLC) method for the simultaneous determination of tolperisone (TP… (More)
Is this relevant?
2000
2000
Stereochemical study of tolperisone, a muscle relaxant agent, by circular dichroism and ultraviolet spectroscopy.
The stereochemistry of tolperisone, a chiral aryl-alkyl basic ketone was investigated by means of circular dichroism (CD) and… (More)
Is this relevant?
1996
1996
Tolperisone: evaluation of the lidocaine-like activity by molecular modeling.
Tolperisone (1), a muscle relaxant with lidocaine-like activity, was compared to lidocaine (2) by molecular modeling methods… (More)
Is this relevant?
1996
1996
Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial.
The efficacy and safety of oral tolperisone hydrochloride (Mydocalm) in the treatment of painful reflex muscle spasm was assessed… (More)
Is this relevant?