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Tolperisone

Known as: 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, Tolperisone [Chemical/Ingredient] 
A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra… Expand
National Institutes of Health

Related topics

Related topics

11 relations
In BloodTolperisone Hydrochlorideagonistsanalogs & derivatives
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Broader (1)

Muscle Relaxants, Central

Narrower (2)

MydetonMydocalm

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Tolperisone: A Typical Representative of a Class of Centrally Acting Muscle Relaxants with Less Sedative Side Effects
Tolperisone, a piperidine derivative, is assigned to the group of centrally acting muscle relaxants and has been in clinical use… Expand
2006
2006
HPLC Determination of tolperisone in human plasma
A simple high performance liquid chromatographic (HPLC) method was developed for the determination of tolperisone in human plasma… Expand
2006
2006
A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms.
The specific, acute interaction of tolperisone, an agent used as a muscle relaxant and for the treatment of chronic pain… Expand
2005
2005
Tolperisone-Type Drugs Inhibit Spinal Reflexes via Blockade of Voltage-Gated Sodium and Calcium Channels
The spinal reflex depressant mechanism of tolperisone and some of its structural analogs with central muscle relaxant action was… Expand
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2005
2005
A randomized, double‐blind, placebo‐controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke
To study the efficacy and safety of tolperisone – a centrally acting muscle relaxant with membrane stabilizing activity – in the… Expand
2003
2003
Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.
The in vitro metabolism of tolperisone, 1-(4-methyl-phenyl)-2-methyl-3-(1-piperidino)-1-propanone-hydrochloride, a centrally… Expand
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2001
2001
Tolperisone--a novel modulator of ionic currents in myelinated axons.
The actions of tolperisone on single intact Ranvier nodes of the toad Xenopus were investigated by means of the Hodgkin-Huxley… Expand
1996
1996
Tolperisone: Evaluation of the Lidocaine‐Like Activity by Molecular Modeling
  • G. Fels
  • Archiv der Pharmazie
  • 1996
    • Corpus ID: 38161223
Tolperisone (1), a muscle relaxant with lidocaine‐like activity, was compared to lidocaine (2) by molecular modeling methods… Expand
1992
1992
Determination of tolperisone enantiomers in plasma and their disposition in rats.
A stereoselective assay for the determination of tolperisone enantiomers in plasma by high performance liquid chromatography was… Expand
Highly Cited
1982
Highly Cited
1982
Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity.
Effects of afloqualone on mono- (MSR) and poly-synaptic reflex (PSR) potentials and alpha- and gamma-rigidities were studied in… Expand
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