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Todralazine

Known as: Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, monohydrochloride, Todrazoline, Todralazine [Chemical/Ingredient] 
An antihypertensive agent with both central and peripheral action; it has some central nervous system depressant effects.
National Institutes of Health

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9 relations

Broader (1)

Antihypertensive Agents

Narrower (1)

Binazine
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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2015
2015
Todralazine protects zebrafish from lethal effects of ionizing radiation: role of hematopoietic cell expansion.
The Johns Hopkins Clinical Compound Library (JHCCL), a collection of Food and Drug Administration (FDA)-approved small molecules… 
2007
2007
A novel mechanism for drug-induced liver failure: inhibition of histone acetylation by hydralazine derivatives.
2001
2001
Impact of four antimutagens on apoptosis in genotoxically damaged lymphocytes in vitro.
An antimutagenic activity of fluphenazine, todralazine, anthocyanins and alkylresorcinols was established in a battery of short… 
2001
2001
A comparison of the methods applied to detect apoptosis in genotoxically-damaged lymphocytes cultured in the presence of four antimutagens.
The sensitivity of the available methods of apoptosis detection in lymphocyte cultures was tested. Cells were preincubated with… 
2000
2000
Evaluation of antimutagenic effect of todralazine in cultured lymphocytes.
Todralazine, an antihypertensive drug from the hydrazinophthalazine group, significantly decreased the activities of benzo[a… 
1997
1997
Inhibition of potassium dichromate mutagenicity by todralazine.
Todralazine, an antihypertensive drug of the hydrazinoph-thalazine group, markedly decreased the mutagenic activity of potassium… 
Highly Cited
1996
Highly Cited
1996
Benidipine improves endothelial function in renal resistance arteries of hypertensive rats.
We studied the effects of long-term antihypertensive treatment on endothelial function in renal resistance arteries from… 
Review
1996
Review
1996
Fulminant hepatic failure caused by ecarazine hydrochloride (a hydralazine derivative)
The cause of fulminant hepatic failure is reported to be unknown in more than half the cases in Japan. We recently reviewed 23… 
1979
1979
[Inhibition of cyclic AMP phosphodiesterase activity by ecarazine hydrochloride, hydralazine and their metabolites (author's transl)].
1978
1978
Antihypertensive and antidiuretic effects of 3-hydrazino-6-[N, N-bis (2-hydroxyethyl) amino]-pyridazine (L 6150) in rats.
3-Hydrazino-6-[N,N-bis (2-hydroxyethyl)amino]-pyridazine (L 6150) has been reported as an antihypertensive vasodilator drug. We… 
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