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Thalidomide Embryopathy Syndrome

Known as: Fetal Thalidomide Syndrome, Thalidomide Embryopathy, Thalidomide-Induced Birth Defect 
Fetal embryopathy associated with maternal thalidomide use during pregnancy characterized by phocomelia of one or all limbs, other limb defects such… 
National Institutes of Health

Related topics

Related topics

3 relations
Beckwith-Wiedemann SyndromeFetal DiseasesPerinatal Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Thalidomide Embryopathy: An Enigmatic Challenge
Thalidomide remains one of the world’s most notorious drugs due to the severe birth defects it induced in children between 1957… 
Highly Cited
2009
Highly Cited
2009
Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation
Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of the developing limbs. The mechanisms… 
Review
2005
Review
2005
Autism associated with conditions characterized by developmental errors in early embryogenesis: a mini review
Highly Cited
2003
Highly Cited
2003
Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients…
We have recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on… 
Review
2000
Review
2000
Hypothesis: thalidomide embryopathy-proposed mechanism of action.
We propose that thalidomide affects the following pathway during limb development: Growth factors (FGF-2 and IGF-I) attach to… 
Review
1999
Review
1999
Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses.
Thalidomide (a-[N-phthalmido]-glutarimide) was synthesized in 1954, in what was then West Germany, by Chemie Grunenthal under the… 
Highly Cited
1994
Highly Cited
1994
AUTISM IN THALIDOMIDE EMBRYOPATHY: A POPULATION STUDY
Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM‐III‐R autistic disorder and… 
Highly Cited
1991
Highly Cited
1991
Ocular motility in thalidomide embryopathy.
Twenty-one individuals, aged 28 to 29 years, with documented thalidomide embryopathy were examined in Sweden. The most noteworthy… 
Review
1988
Review
1988
Proposed mechanisms of action in thalidomide embryopathy.
Highly Cited
1985
Highly Cited
1985
Teratogen update: clinical aspects of thalidomide embryopathy--a continuing preoccupation.
There is much misinformation in the medical community regarding the thalidomide syndrome. Some physicians and scientists are… 
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