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Tebipenem Pivoxil

An orally available pivaloyloxymethyl ester prodrug of tebipenem, a broad-spectrum 1-beta-methylcarbapenem antibiotic with a 1-(1,3-thiazolin-2-yl… 
National Institutes of Health

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ME1211

Papers overview

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2019
2019
Cyclodextrins as multifunctional excipients: Influence of inclusion into β-cyclodextrin on physicochemical and biological properties of tebipenem pivoxil
A novel approach for drug design based on the oral carbapenem analog tebipenem pivoxil (TP) has been proposed. The formation of… 
2016
2016
Antibacterial Properties of Tebipenem Pivoxil Tablet, a New Oral Carbapenem Preparation against a Variety of Pathogenic Bacteria in Vitro and in Vivo
Aims: To systemically investigate the in vitro and in vivo antibacterial properties of tebipenem pivoxil tablet. In addition… 
2015
2015
Prediction of HPLC retention times of tebipenem pivoxyl and its degradation products in solid state by applying adaptive artificial neural network with recursive features elimination.
2015
2015
The chromatographic approach to kinetic studies of tebipenem pivoxil.
A validated high-performance liquid chromatography-diode array detector (HPLC-DAD) method for stability studies of tebipenem… 
2015
2015
First case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem.
OBJECTIVE A patient presented with convulsive seizures when sodium valproate (VPA) and tebipenem pivoxil (Orapenem) were co… 
2014
2014
Tebipenem, a New Carbapenem Antibiotic, Is a Slow Substrate That Inhibits the β-Lactamase from Mycobacterium tuberculosis
The genome of Mycobacterium tuberculosis contains a gene, blaC, which encodes a highly active β-lactamase (BlaC). We have… 
2009
2009
[Convulsive liability of an oral carbapenem antibiotic, tebipenem pivoxil].
Tebipenem pivoxil (TBPM-PI), the first oral carbapenem antibiotic both in Japan and abroad, was examined on its convulsive… 
2008
2008
Population pharmacokinetics of tebipenem pivoxil (ME1211), a novel oral carbapenem antibiotic, in pediatric patients with otolaryngological infection or pneumonia.
Tebipenem pivoxil (TBPM-PI, ME1211) has been under development as the world's first oral carbapenem for treatment of… 
2008
2008
Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae
ABSTRACT Biapenem is a parenteral carbapenem antibiotic that exhibits wide-ranging antibacterial activity, remarkable chemical… 
2006
2006
Tebipenem Pivoxil/Tebipenem
Tebipenem pivoxil is a novel oral carbapenem antibiotic candidate, a pivaloyloxymethyl ester prodrug of tebipenem. The potent… 
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