Talnetant
National Institutes of Health
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Tachykinins (TKs) are a family of endogenous peptides widely expressed in the central and in the peripheral nervous systems as…
The NK(3) subtype of tachykinin receptor is a G protein-coupled receptor that is a potential therapeutic target for several…
Background Previous studies have shown a reduction in cough response to inhaled citric acid after blocking NK1, NK2 and also NK3…
The reflex response to distension of the small intestine in vivo is complex and not well understood. The aim of this study was to…
Talnetant and osanetant, two structurally diverse antagonists of neurokinin-3 receptor (NK3), displayed distinct modes of action…
1. NK(3) tachykinin receptors mediate slow excitatory transmission in the enteric nervous system and play a role in reflexes…
Talnetant (SB-223412) is a selective, orally active NK3 antagonist based on 4-quinolinecarboxamide, and is under development by…
This review describes the patent applications and relevant scientific literature published during 2002 in the field of novel…