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TY 51469

Known as: TY-51469, TY51469 
National Institutes of Health

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2 relations

Broader (2)

SulfonamidesThiophenes

Papers overview

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2016
2016
Chymase inhibitor TY-51469 in therapy of inflammatory bowel disease.
AIM To investigate the effect of chymase inhibitor TY-51469 in the therapy of inflammatory bowel disease and the underlying… 
2016
2016
Effect of TY-51469 on macrophage pattern in mice subjected fatigue exercise
2014
2014
Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats
Objective: To clarify the role of chymase in hypertension, we evaluated the effect of a chymase inhibitor, TY-51469, on vascular… 
2014
2014
Chymase Inhibition Attenuates Lipopolysaccharide/ D-Galactosamine-Induced Acute Liver Failure in Hamsters
Background/Aims: Chymase inhibition has been shown to attenuate matrix metalloproteinase (MMP)-9 and tumor necrosis factor (TNF… 
2013
2013
Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non‐alcoholic steatohepatitis in hamsters fed a methionine‐ and choline‐deficient diet
Chymase plays a role in the augmentation of angiotensin II formation, which is involved in liver fibrosis. The therapeutic… 
2012
2012
Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.
2012
2012
Effect of chymase inhibitors on dimethylnitrosamine- induced rat liver fibrosis and on chymase and collagen I expression
Chymase converts angiotensin (Ang) I to Ang II, which may promote the development of liver fibrosis. In this study, a chymase… 
2010
2010
The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice
2009
2009
Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes.
Angiotensin II may be involved in pancreatic disorganization, but the involvement of chymase has been unclear. In the present… 
2009
2009
S1607 A Specific Chymase Inhibitor TY-51469 Suppressed Tetrachloride-Induced Liver Fibrosis in a Hamster Model
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