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TRU 016

Known as: TRU-016 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Immunoglobulin GRecombinant Fusion Proteins

Narrower (1)

otlertuzumab

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Otlertuzumab (TRU‐016), an anti‐CD37 monospecific ADAPTIR™ therapeutic protein, for relapsed or refractory NHL patients
CD37 is cell surface tetraspanin present on normal and malignant B cells. Otlertuzumab (TRU‐016) is a novel humanized anti‐CD37… Expand
2013
2013
Phase 2 Study Of Otlertuzumab (TRU-016), An Anti-CD37 ADAPTIRTM Protein, In Combination With Bendamustine Vs Bendamustine Alone In Patients With Relapsed Chronic Lymphocytic Leukemia (CLL)
Background CD37 is a tetraspanin protein expressed on the surface of normal and transformed B-cells across a wide range of… Expand
Review
2013
Review
2013
Emerging monoclonal antibodies and related agents for the treatment of chronic lymphocytic leukemia.
  • T. Robak
  • Future oncology
  • 2013
    • Corpus ID: 24188848
Monoclonal antibodies (mAbs) - rituximab, ofatumumab and alemtuzumab - have been approved for use in the therapy of chronic… Expand
2011
2011
Phase 1 Study of Tru-016, An Anti-CD37 SMIP™ Protein in Naïve and Relapsed and/or Refractory CLL Patients
Abstract 1792 Background: CD37 is a tetraspanin protein expressed on the surface of normal and transformed B-cells across a wide… Expand
2010
2010
Phase 1 Dose Escalation Study of TRU-016, An Anti-CD37 SMIP™ Protein In Relapsed and Refractory CLL
Abstract 56 Background: CD37 is a member of the tetraspanin superfamily of molecules which are implicated in diverse processes… Expand
2010
2010
TRU-016, An Anti-CD37 SMIP™ Biologic, In Combination with Other Therapeutic Drugs In Models of Non-Hodgkin's Lymphoma
Abstract 3931 Background: CD37 is a 50–55 kDa heavily glycosylated member of the tetraspanin superfamily of molecules. This cell… Expand
Review
2009
Review
2009
TRU-016, a humanized anti-CD37 IgG fusion protein for the potential treatment of B-cell malignancies.
TRU-016, under development by Trubion Pharmaceuticals Inc and Facet Biotech Corp, is an intravenously administered anti-CD37 IgG… Expand
2009
2009
Evaluation of the effect of TRU-016, an anti-CD37 directed SMIP in combination with other therapeutic drugs in models of non-Hodgkin's lymphoma.
8571 Background: TRU-016, a single chain anti-CD37 Fc fusion molecule has been shown to display pro-apoptotic and Fc-dependent… Expand
2009
2009
A phase I trial of TRU-016, an anti-CD37 small modular immunopharmaceutical (SMIP) in relapsed and refractory CLL.
3017 Background: CD37 is a tetraspan family member expressed predominantly on normal and transformed B-cells across a wide range… Expand
2009
2009
A Phase 1 Trial of TRU-016, An Anti-CD37 Small Modular Immunopharmaceutical (SMIPTM) Protein in Relapsed and Refractory CLL: Early Promising Clinical Activity.
Abstract 3424 Poster Board III-312 Background CD37 is a tetraspanin family member expressed predominantly on normal and… Expand
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