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TRPV6 Calcium Channel Inhibitor SOR-C13

Known as: SOR-C13 
An inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity… 
National Institutes of Health

Papers overview

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2018
2018
Abstract 1936: The central role of NFAT signalling in the mechanism of action of the TRPV6 oncochannel inhibitor and clinical candidate SOR-C13
SOR-C13, a 13-mer peptide derived from soricidin, the paralytic peptide in saliva of the Northern Short-tailed shrew, has… 
Highly Cited
2017
Highly Cited
2017
First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors
SummaryIntroduction This was an open-label, dose escalation (3 + 3 design), Phase I study of SOR-C13 in patients with advanced… 
2017
2017
Erratum to: First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors
2016
2016
Abstract LB-051: Cancer cell binding, internalization and intracellular localization of a novel therapeutic peptide SOR-C13 targeting the TRPV6 oncochannel
SOR-C13, a 13-mer peptide derived from soricidin, the paralytic protein component of saliva of the Northern Short-tailed shrew… 
2014
2014
IL-21-inducible TRPV6 is reduced in psoriatic skin
2012
2012
Stability-improved organic n-channel thin-film transistors with nm-thin hydrophobic polymer-coated high-k dielectrics.
We report on the fabrication of N,N'-ditridecyl-perylene-3,4:9,10-tetracarboxylic diimide-C13 (PTCDI-C13), n-channel organic thin… 
2010
2010
Role of As_2S_2 on C13K/DDP Cells Proliferation and Apoptosis in vitro
Objective To investigate the role of As2S2 on C13K/DDP cells proliferation and apoptosis in vitro.Methods C13K/DDP cells were… 
2007
2007
Cloning and functional identification of novel endothelin receptor type A isoforms in pituitary.
Mammalian endothelin (ET) receptors, termed ET(A)R and ET(B)R, are derived from two intron-containing genes and the functional… 
Highly Cited
2004
Highly Cited
2004
The tomato carotenoid cleavage dioxygenase 1 genes contribute to the formation of the flavor volatiles beta-ionone, pseudoionone, and geranylacetone.
Volatile terpenoid compounds, potentially derived from carotenoids, are important components of flavor and aroma in many fruits… 
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