TPX2 gene

Known as: C20ORF1, TPX2, microtubule-associated, DIL-2 
This gene plays a role in the assembly of the mitotic spindle.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
010203019972017

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND The formation of a bipolar spindle is an essential step during cell division. Bipolar spindle assembly is driven by… (More)
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Highly Cited
2008
Highly Cited
2008
To assemble mitotic spindles, cells nucleate microtubules from a variety of sources including chromosomes and centrosomes. We… (More)
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Highly Cited
2005
Highly Cited
2005
Aurora family serine/threonine kinases control mitotic progression, and their deregulation is implicated in tumorigenesis. Aurora… (More)
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Highly Cited
2003
Highly Cited
2003
Aurora-A is an oncogenic kinase essential for mitotic spindle assembly. It is activated by phosphorylation and by the microtubule… (More)
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Highly Cited
2003
Highly Cited
2003
Segregation of chromosomes during mitosis requires interplay between several classes of protein on the spindle, including protein… (More)
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Highly Cited
2002
Highly Cited
2002
Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human… (More)
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Highly Cited
2002
Highly Cited
2002
In Xenopus laevis egg extracts, TPX2 is required for the Ran-GTP-dependent assembly of microtubules around chromosomes. Here we… (More)
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Highly Cited
2001
Highly Cited
2001
The small GTPase Ran, bound to GTP, is required for the induction of spindle formation by chromosomes in M phase. High… (More)
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Highly Cited
2001
Highly Cited
2001
spindle assembly in Xenopus egg extracts in the pres-European Molecular Biology Laboratory ence of inhibitors of chromosome… (More)
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Highly Cited
2000
Highly Cited
2000
TPX2, the targeting protein for Xenopus kinesin-like protein 2 (Xklp2), was identified as a microtubule-associated protein that… (More)
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