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TPBG gene

Known as: M6P1, 5T4-AG, TROPHOBLAST GLYCOPROTEIN 
National Institutes of Health

Related topics

Related topics

1 relation
Pregnancy-Specific beta 1-Glycoproteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Combining data from TCGA and GEO databases and reverse transcription quantitative PCR validation to identify gene prognostic markers in lung cancer
Background The aim of this study was to predict and explore the possible mechanism and clinical value of genetic markers in the… 
2015
2015
First-in-human dose escalation, safety, and PK study of a novel EFNA4-ADC in patients with advanced solid tumors.
2520 Background: PF-06647263 is an anti-EFNA4 antibody drug conjugate (ADC) comprised of a humanized mAb (huE22), a hydrazine… 
2015
2015
Phenotype of TPBG Gene Replacement in the Mouse and Impact on the Pharmacokinetics of an Antibody-Drug Conjugate.
The use of predictive preclinical models in drug discovery is critical for compound selection, optimization, preclinical to… 
Review
2015
Review
2015
Late-Breaking Basic Science Abstracts From the American Heart Association’s Scientific Sessions 2015
Background: Small studies suggested circulating microRNAs (circmiRs) as biomarkers for Heart Failure (HF). However, standardized… 
2014
2014
Association of oncofetal protein expression with clinical outcomes in patients with urothelial carcinoma of the bladder.
2013
2013
Escalating Regulation of 5T4-Specific IFN-γ+ CD4+ T Cells Distinguishes Colorectal Cancer Patients from Healthy Controls and Provides a Target for In Vivo Therapy
Using overlapping peptides spanning oncofetal antigen 5T4 as targets, Scurr and colleagues identify an inverse correlation… 
2013
2013
Abstract 4752: Preclinical development and translational research on a novel antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Antibody-drug conjugates (ADCs) represent a… 
2012
2012
Abstract 2530: Long-term tumor regression induced by a novel antibody drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Antibody-drug conjugates (ADCs) represent a… 
2010
2010
Trophoblast Glycoprotein: Possible Candidate Mediating Podocyte Injuries in Glomerulonephritis
Background: Trophoblast glycoprotein (Tpbg), a 72-kDa transmembrane glycoprotein, is known to regulate the phenotypes of… 
Highly Cited
2006
Highly Cited
2006
Active treatment of murine tumors with a highly attenuated vaccinia virus expressing the tumor associated antigen 5T4 (TroVax) is CD4+ T cell dependent and antibody mediated
Abstract5T4 is a tumor associated antigen that is expressed on the surface of a wide spectrum of human adenocarcinomas. The… 
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