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TP53*1 Allele

Known as: TP53 Codon 72 Polymorphism, TP53 P72A, TP53 c.215C>G 
Human TP53*1 allele is located in the vicinity of 17p13.1 and is approximately 19 kb in length. This allele, which encodes cellular tumor antigen p53… 
National Institutes of Health

Related topics

Related topics

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17p13.1Adenocarcinoma Of EsophagusAdenocarcinoma of ampulla of VaterAdenocarcinoma of the Gastroesophageal Junction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Association of TP53 rs1042522 with cervical cancer in the sub‐Saharan African population: a meta‐analysis
TP53 plays a crucial role in preventing cancer development. Previous studies in sub‐Saharan Africa (SSA) reported inconclusive… 
2017
2017
Relevance of DNA repair gene polymorphisms to gastric cancer risk and phenotype
Variations in DNA repair genes have been reported as key factors in gastric cancer (GC) susceptibility but results among studies… 
2016
2016
Association between TP53 Arg72Pro polymorphism and leukemia risk: a meta-analysis of 14 case-control studies
The relationship between the TP53 Arg72Pro polymorphism (rs1042522) and the risk of leukemia remains controversial. Consequently… 
2015
2015
Evolutionary Adaptations to Risk of Cancer: Evidence From Cancer Resistance in Elephants.
  • M. GreavesL. Ermini
  • Journal of the American Medical Association (JAMA…
  • 2015
  • Corpus ID: 205063943
Paradoxes can be intellectually challenging and illuminating.TheeponymousPetoparadoxoriginatedapproximately40 years agowhenPeto… 
2013
2013
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma
PurposeWe examined the influence of XPC A2920C, XPF T30028C, TP53 Arg72Pro and GSTP1 Ile105Val polymorphisms in the risk of… 
2012
2012
Association between TP53 Arg72Pro polymorphism and hepatocellular carcinoma risk: a meta-analysis.
BACKGROUND Previous studies on the association between the TP53 Arg72Pro polymorphism and hepatocellular carcinoma (HCC) risk… 
Highly Cited
2011
Highly Cited
2011
Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans
Aims A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2… 
2010
2010
Pro variant of TP53 Arg72Pro contributes to esophageal squamous cell carcinoma risk: evidence from a meta-analysis
The TP53 Arg72Pro polymorphism has been investigated as a potential genetic hallmark of esophageal cancer, but studies… 
2009
2009
Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients
IntroductionSomatic inactivation of the TP53 gene in breast tumors is a marker for poor outcome, and breast cancer outcome might… 
Highly Cited
2006
Highly Cited
2006
Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity.
Benzene is a recognized hematotoxicant and carcinogen that produces genotoxic damage. DNA double-strand breaks (DSB) are one of… 
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