TOR signaling

Known as: TOR signaling pathway, target of rapamycin signalling pathway, TOR signaling cascade 
A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
0204019962018

Papers overview

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Highly Cited
2009
Highly Cited
2009
Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including… (More)
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Highly Cited
2007
Highly Cited
2007
The relationships between mitochondrial respiration, reactive oxygen species (ROS), and life span are complex and remain… (More)
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Highly Cited
2006
Highly Cited
2006
Chronological life span (CLS) in Saccharomyces cerevisiae, defined as the time cells in a stationary phase culture remain viable… (More)
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Highly Cited
2004
Highly Cited
2004
In many species, reducing nutrient intake without causing malnutrition extends lifespan. Like DR (dietary restriction… (More)
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Highly Cited
2004
Highly Cited
2004
The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process whereby… (More)
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Highly Cited
2003
Highly Cited
2003
The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in… (More)
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Highly Cited
2002
Highly Cited
2002
The target of rapamycin (TOR) proteins in Saccharomyces cerevisiae, TOR1 and TOR2, redundantly regulate growth in a rapamycin… (More)
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Highly Cited
1999
Highly Cited
1999
The rapamycin-sensitive TOR signalling pathway in Saccharomyces cerevisiae activates a cell-growth program in response to… (More)
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Highly Cited
1999
Highly Cited
1999
Rapamycin inhibits the TOR kinases, which regulate cell proliferation and mRNA translation and are conserved from yeast to man… (More)
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Highly Cited
1999
Highly Cited
1999
The TOR (target of rapamycin) signal transduction pathway is an important mechanism by which cell growth is controlled in all… (More)
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