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TOP2B gene

Known as: TOP2B, Topoisomerase (DNA) II Beta 180kDa Gene, topoisomerase (DNA) II beta 
This gene is involved in chromosome recombination, DNA replication and the regulation of DNA topology during transcription.
National Institutes of Health

Related topics

Related topics

6 relations
Chromosome CondensationDNA ReplicationDNA Topology RegulationDNA topoisomerase II beta

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Mining topoisomerase isoforms in gastric cancer.
2020
2020
Copy number variations of TOP2B gene are associated with growth traits in Chinese sheep breeds
Abstract Copy number variations are primary source of genetic variations, which are associated with essential traits in many… 
2019
2019
The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
2,6-Diaminopyridine-3,5-bis(thiocyanate) (PR-619) is a broad-spectrum deubiquitinating enzyme (DUB) inhibitor that has been… 
2019
2019
Clarifying the Mechanism of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα and IIβ.
Cells utilize type II topoisomerases to alleviate topological strain in DNA associated with replication and transcription and to… 
2018
2018
Copper-Catalyzed Synthesis, Bio-Evaluation, and in Silico Studies of 2-Aryl-N-alkylbenzimidazoles as Neuroprotective Agents
2-aryl-N-alkylbenzimidazole derivatives synthesized by CuI/PPh3 promoted direct coupling of N-alkylbenzimidazoles with aryl… 
2014
2014
Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2β expression to TMPRSS2-ERG fusion status in prostate cancer.
Fusion of TMPRSS2 with ERG in prostate cells is determined by double-strand DNA breaks induced by androgen signaling and… 
2013
2013
TOP2β is essential for ovarian follicles that are hypersensitive to chemotherapeutic drugs.
The mechanisms underlying chemotherapy-induced acceleration of ovarian insufficiency are not fully understood, particularly for… 
2010
2010
Targeting PKCδ-mediated topoisomerase IIβ overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line
Retinoic acid (RA) relieves the maturation block in t(15:17) acute promyelocytic leukemia (APL), leading to granulocytic… 
2004
2004
Analysis of topoisomerase (TOP) expression in peripheral blood mononuclear cell (PBMCs) from patients (PTS) undergoing chemotherapy (CHT) for solid tumors(ST)
2124 Background: Clinical experience demonstrated the efficacy of combined drug regimens, including inhibitors of DNA replication… 
2002
2002
Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites.
Eukaryotic topoisomerase II (topo II) catalyses topological genomic changes essential for chromosome segregation, chromatin… 
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