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TOP2B gene

Known as: TOP2B, Topoisomerase (DNA) II Beta 180kDa Gene, topoisomerase (DNA) II beta 
This gene is involved in chromosome recombination, DNA replication and the regulation of DNA topology during transcription.
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Type II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand… Expand
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Highly Cited
2017
Highly Cited
2017
In this study, we show that evolutionarily conserved chromosome loop anchors bound by CCCTC-binding factor (CTCF) and cohesin are… Expand
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Highly Cited
2014
Highly Cited
2014
BackgroundThe bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited… Expand
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Highly Cited
2013
Highly Cited
2013
  • D. Sawyer
  • The New England journal of medicine
  • 2013
  • Corpus ID: 18165419
Doxorubicin and other anthracyclines are used to treat cancer, yet they elevate the risk of heart failure. A recent study… Expand
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Highly Cited
2010
Highly Cited
2010
DNA double-strand breaks (DSBs) can lead to the development of genomic rearrangements, which are hallmarks of cancer. Fusions… Expand
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Highly Cited
2008
Highly Cited
2008
Abstract A precise packaging of the paternal genome during spermiogenesis is essential for fertilization and embryogenesis. Most… Expand
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2007
2007
Abstract We have demonstrated that mouse spermatozoa can cleave their DNA into 50-kb fragments when treated with Triton X-100… Expand
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Highly Cited
2006
Highly Cited
2006
Abstract We previously demonstrated that mammalian spermatozoa contain a nuclease activity that cleaves DNA into loop-sized… Expand
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Highly Cited
2006
Highly Cited
2006
BackgroundAn essential part of using real-time RT-PCR is that expression results have to be normalized before any conclusions can… Expand
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Highly Cited
1998
Highly Cited
1998
Eucaryotic topoisomerase II is an essential nuclear enzyme involved in processes such as chromosome condensation, chromatid… Expand
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