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TNS2 gene

Known as: TENSIN-LIKE C1 DOMAIN-CONTAINING PHOSPHATASE, C1TEN, TENC1 
National Institutes of Health

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TNS2 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Deletion of the Tensin2 SH2-PTB domain, but not the loss of its PTPase activity, induces podocyte injury in FVB/N mouse strain
Tensin2 (TNS2) is a focal adhesion-localized protein possessing N-terminal tandem protein tyrosine phosphatase (PTPase) and C2… 
Highly Cited
2018
Highly Cited
2018
Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment
No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney disease. Here we show mutations in… 
2018
2018
AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells
TNS2 is a focal adhesions protein and a binding partner for many proteins, including the receptor tyrosine kinase Axl. Although… 
2018
2018
Cellular phosphatase activity of C1-Ten/Tensin2 is controlled by Phosphatidylinositol-3,4,5-triphosphate binding through the C1-Ten/Tensin2 SH2 domain.
2017
2017
C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation
Hypertrophy is a prominent feature of damaged podocytes in diabetic kidney disease (DKD). mTORC1 hyperactivation leads to… 
2014
2014
Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation.
2013
2013
C1-Ten Is a Protein Tyrosine Phosphatase of Insulin Receptor Substrate 1 (IRS-1), Regulating IRS-1 Stability and Muscle Atrophy
ABSTRACT Muscle atrophy occurs under various catabolic conditions, including insulin deficiency, insulin resistance, or increased… 
2013
2013
Tenc1-Deficient Mice Develop Glomerular Disease in a Strain-Specific Manner
Background/Aims: Tenc1 (also known as tensin2) is an integrin-associated focal adhesion molecule that is broadly expressed in… 
2011
2011
1H, 15N and 13C chemical shift assignments of the SH2 domain of human tensin2 (TENC1)
Tensin is an important cytoplasmic phosphoprotein localized to integrin-mediated focal adhesion. It links actin cytoskeleton to… 
Highly Cited
2005
Highly Cited
2005
C1‐TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration
We have previously identified C1 domain‐containing phosphatase and TENsin homologue (C1‐TEN) as being an intracellular binding… 
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