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TMOD4 gene

Known as: actin-capping protein, Sk-Tmod, skeletal tropomodulin 
 
National Institutes of Health

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Actin Capping Proteins

Papers overview

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2015
2015
Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis
ABSTRACT Precise regulation of thin filament length is essential for optimal force generation during muscle contraction. The thin… Expand
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2015
2015
Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle
The sarcomeric tropomodulin (Tmod) isoforms Tmod1 and Tmod4 cap thin filament pointed ends and functionally interact with the… Expand
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2014
2014
Pointed‐end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers
In skeletal muscle, thick and thin filaments are arranged in a myofibrillar lattice. Tropomodulin 1 (Tmod1) is a pointed‐end… Expand
2014
2014
Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle
Calpain-mediated proteolysis of the thin filament pointed-end–capping protein tropomodulin results in actin subunit association… Expand
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2012
2012
Alteration of Tropomyosin-binding Properties of Tropomodulin-1 Affects Its Capping Ability and Localization in Skeletal Myocytes*
Background: Tropomodulin is a tropomyosin-dependent actin-capping protein. Results: Mutations in tropomodulin-1 that reduce its… Expand
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2011
2011
Cytoplasmic γ-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers
Tropomodulins, cytoplasmic γ-actin, and small ankyrin 1.5 mechanically stabilize the sarcoplasmic reticulum and maintain… Expand
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Highly Cited
2010
Highly Cited
2010
Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology
In skeletal muscle fibers, tropomodulin 1 (Tmod1) can be compensated for, structurally but not functionally, by Tmod3 and -4. 
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2003
2003
Tropomodulin binds to filensin intermediate filaments
Tropomodulin (Tmod) is an actin filament pointed end capping protein found in the membrane skeleton of lens fiber cells. We… Expand
Highly Cited
2000
Highly Cited
2000
Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.
Tropomodulin (TMOD) is the actin-capping protein for the slow-growing end of filamentous actin, and a neuronal-specific isoform… Expand
Highly Cited
1999
Highly Cited
1999
Identification of a Novel Tropomodulin Isoform, Skeletal Tropomodulin, That Caps Actin Filament Pointed Ends in Fast Skeletal Muscle*
Tropomodulin (E-Tmod) is an actin filament pointed end capping protein that maintains the length of the sarcomeric actin… Expand
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