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TMC647055

 
National Institutes of Health

Papers overview

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2017
2017
BackgroundIn study TMC647055HPC2001, a 3-direct-acting-antiviral (DAA) regimen combining NS3/4A protease inhibitor simeprevir… Expand
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2017
2017
BackgroundA Phase 2a, open-label study (NCT01724086) was conducted to assess the efficacy and safety of a once-daily, 2-direct… Expand
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2016
2016
NS5B polymerase plays an important role in viral replication machinery. TMC647055 (TMC) is a novel and potent non-nucleoside… Expand
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2015
2015
NS5B polymerase plays an important role in the viral replication machinery. TMC647055 is a novel and potent nonnucleoside… Expand
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2014
2014
Structure-based macrocyclization of a 6-carboxylic acid indole chemotype has yielded potent and selective finger-loop inhibitors… Expand
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2012
2012
Hepatitis C virus (HCV) infection is a major global health burden and is associated with an increased risk of liver cirrhosis and… Expand
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2012
2012
Optimization of a novel series of macrocyclic indole-based inhibitors of the HCV NS5b polymerase targeting the finger loop domain… Expand
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