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TMC1 gene

Known as: transmembrane channel like 1, TRANSMEMBRANE COCHLEAR-EXPRESSED GENE 1, TMC1 
 
National Institutes of Health

Related topics

Related topics

5 relations
TMC2 geneTMC3 geneTMC4 geneTMC5 gene
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Papers overview

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Highly Cited
2018
Highly Cited
2018
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
The proteins that form the permeation pathway of mechanosensory transduction channels in inner-ear hair cells have not been… Expand
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2016
2016
Recessive mutations of TMC1 associated with moderate to severe hearing loss
TMC1 encodes a protein required for the normal function of mechanically activated channels that enable sensory transduction in… Expand
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2016
2016
Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response*
The ubiquitin-proteasome system represents the major pathway of selective intracellular protein degradation in eukaryotes… Expand
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Highly Cited
2015
Highly Cited
2015
Tmc gene therapy restores auditory function in deaf mice
Injection of AAV vectors that encoded wild-type Tmc1 or Tmc2 restores auditory function in mouse models of human deafnesses DFNB7… Expand
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2015
2015
A novel mutation in the TMC1 gene causes non-syndromic hearing loss in a Moroccan family.
Autosomal recessive non-syndromic hearing loss (ARNSHL) is one of the most common genetic diseases in human and is subject to… Expand
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Highly Cited
2014
Highly Cited
2014
Subunit determination of the conductance of hair-cell mechanotransducer channels
Significance Cochlear hair cells are sensory receptors of the inner ear that detect sound via opening of mechanically sensitive… Expand
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2014
2014
Mutations of TMC1 cause deafness by disrupting mechanoelectrical transduction.
OBJECTIVE Mutations of transmembrane channel-like 1 gene (TMC1) can cause dominant (DFNA36) or recessive (DFNB7/B11) deafness. In… Expand
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Highly Cited
2013
Highly Cited
2013
TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear
Sensory transduction in auditory and vestibular hair cells requires expression of transmembrane channel-like (Tmc) 1 and 2 genes… Expand
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2009
2009
Amino acid 572 in TMC1: hot spot or critical functional residue for dominant mutations causing hearing impairment
Two different missense mutations, p.D572N and p.D572H, affecting the same nucleotide and codon of the TMC1 gene were earlier… Expand
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Highly Cited
2002
Highly Cited
2002
Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function
Positional cloning of hereditary deafness genes is a direct approach to identify molecules and mechanisms underlying auditory… Expand
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