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TMC1 gene
Known as:
transmembrane channel like 1
, TRANSMEMBRANE COCHLEAR-EXPRESSED GENE 1
, TMC1
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National Institutes of Health
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Related topics
Related topics
5 relations
TMC2 gene
TMC3 gene
TMC4 gene
TMC5 gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells
M. Beurg
,
A. Barlow
,
D. Furness
,
R. Fettiplace
Proceedings of the National Academy of Sciences
2019
Corpus ID: 202746647
Significance Cochlear hair cells transduce sound into electrical signals by activation of mechanically sensitive ion channels…
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Highly Cited
2018
Highly Cited
2018
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
B. Pan
,
Nurunisa Akyuz
,
+11 authors
J. R. Holt
Neuron
2018
Corpus ID: 52076959
2018
2018
Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function
H. Nakanishi
,
K. Kurima
,
+5 authors
A. Griffith
Scientific Reports
2018
Corpus ID: 52001622
Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1∆/∆ mice are deaf…
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2016
2016
Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response*
A. Guerra-Moreno
,
John Hanna
Journal of Biological Chemistry
2016
Corpus ID: 13737222
The ubiquitin-proteasome system represents the major pathway of selective intracellular protein degradation in eukaryotes…
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Highly Cited
2015
Highly Cited
2015
Tmc gene therapy restores auditory function in deaf mice
Charles Askew
,
C. Rochat
,
+6 authors
J. R. Holt
Science Translational Medicine
2015
Corpus ID: 40291590
Injection of AAV vectors that encoded wild-type Tmc1 or Tmc2 restores auditory function in mouse models of human deafnesses DFNB7…
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Highly Cited
2014
Highly Cited
2014
Subunit determination of the conductance of hair-cell mechanotransducer channels
M. Beurg
,
Wei Xiong
,
Bo Zhao
,
U. Müller
,
R. Fettiplace
Proceedings of the National Academy of Sciences
2014
Corpus ID: 20733725
Significance Cochlear hair cells are sensory receptors of the inner ear that detect sound via opening of mechanically sensitive…
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2014
2014
Mutations of TMC1 cause deafness by disrupting mechanoelectrical transduction.
H. Nakanishi
,
K. Kurima
,
Yoshiyuki Kawashima
,
A. Griffith
Auris, nasus, larynx
2014
Corpus ID: 3987794
2014
2014
Autosomal recessive non-syndromic hearing loss is caused by novel compound heterozygous mutations in TMC1 from a Tibetan Chinese family.
Fangzhu Lin
,
De-qi Li
,
Ping Wang
,
Dongyan Fan
,
Ji De
,
Wei Zhu
International Journal of Pediatric…
2014
Corpus ID: 7825124
Highly Cited
2013
Highly Cited
2013
TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear
B. Pan
,
G. Géléoc
,
+6 authors
J. R. Holt
Neuron
2013
Corpus ID: 721741
Highly Cited
2002
Highly Cited
2002
Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function
K. Kurima
,
L. M. Peters
,
+22 authors
A. Griffith
Nature Genetics
2002
Corpus ID: 40110588
Positional cloning of hereditary deafness genes is a direct approach to identify molecules and mechanisms underlying auditory…
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