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TMC1 gene

Known as: transmembrane channel like 1, TRANSMEMBRANE COCHLEAR-EXPRESSED GENE 1, TMC1 
National Institutes of Health

Papers overview

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2019
2019
Significance Cochlear hair cells transduce sound into electrical signals by activation of mechanically sensitive ion channels… 
2018
2018
Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1∆/∆ mice are deaf… 
2016
2016
The ubiquitin-proteasome system represents the major pathway of selective intracellular protein degradation in eukaryotes… 
Highly Cited
2015
Highly Cited
2015
Injection of AAV vectors that encoded wild-type Tmc1 or Tmc2 restores auditory function in mouse models of human deafnesses DFNB7… 
Highly Cited
2014
Highly Cited
2014
Significance Cochlear hair cells are sensory receptors of the inner ear that detect sound via opening of mechanically sensitive… 
Highly Cited
2002
Highly Cited
2002
Positional cloning of hereditary deafness genes is a direct approach to identify molecules and mechanisms underlying auditory…