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TMC1 gene

Known as: transmembrane channel like 1, TRANSMEMBRANE COCHLEAR-EXPRESSED GENE 1, TMC1 
National Institutes of Health

Related topics

Related topics

5 relations
TMC2 geneTMC3 geneTMC4 geneTMC5 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells
Significance Cochlear hair cells transduce sound into electrical signals by activation of mechanically sensitive ion channels… 
Highly Cited
2018
Highly Cited
2018
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
2018
2018
Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function
Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1∆/∆ mice are deaf… 
2016
2016
Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response*
The ubiquitin-proteasome system represents the major pathway of selective intracellular protein degradation in eukaryotes… 
Highly Cited
2015
Highly Cited
2015
Tmc gene therapy restores auditory function in deaf mice
Injection of AAV vectors that encoded wild-type Tmc1 or Tmc2 restores auditory function in mouse models of human deafnesses DFNB7… 
Highly Cited
2014
Highly Cited
2014
Subunit determination of the conductance of hair-cell mechanotransducer channels
Significance Cochlear hair cells are sensory receptors of the inner ear that detect sound via opening of mechanically sensitive… 
2014
2014
Mutations of TMC1 cause deafness by disrupting mechanoelectrical transduction.
2014
2014
Autosomal recessive non-syndromic hearing loss is caused by novel compound heterozygous mutations in TMC1 from a Tibetan Chinese family.
Highly Cited
2013
Highly Cited
2013
TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear
Highly Cited
2002
Highly Cited
2002
Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function
Positional cloning of hereditary deafness genes is a direct approach to identify molecules and mechanisms underlying auditory… 
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