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TMC 435350

Known as: 435350, TMC, TMC-435350, TMC435350 
 
National Institutes of Health

Papers overview

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2014
2014
Simeprevir (also known as TMC435 or TMC435350) is a novel hepatitis C protease inhibitor. A validated high-performance liquid… Expand
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2013
2013
To facilitate studies of hepatitis C virus (HCV) NS4A, we aimed at developing J6/JFH1-based recombinants with genotype 1- to 7… Expand
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2011
2011
Development of vaccines in autoimmune diseases has received wide attention over the last decade. However, many vaccines showed… Expand
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Highly Cited
2009
Highly Cited
2009
The hepatitis C virus (HCV) NS3/4A serine protease has been explored as a target for the inhibition of viral replication in… Expand
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2008
2008
BACKGROUND & AIMS Expression of the nonstructural protein (NS)3/4A protease in cells infected with hepatitis C virus (HCV… Expand
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2008
2008
SAR analysis performed with a limited set of cyclopentane-containing macrocycles led to the identification of N-[17-[2-(4… Expand
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2008
2008
Methods: TMC435350 as an oral solution in PEG400 was taken with food. Healthy volunteers were divided in 4 panels of maximum 9… Expand
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2007
2007
t max, hour* 5.0 (3.0 - 6.0) 5.0 (4.0 - 6.0) 6.0 (4.0 - 6.0) 6.0 (4.0 - 6.0) 6.0 (4.0 - 6.0) 6.0 (4.0 - 6.0) 
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