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TMC 353121

Known as: TMC-353121, TMC353121 
National Institutes of Health

Papers overview

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2014
2014
Computer-aided design, synthesis andevaluation of novel antiviralcompounds
RNA viruses are a major cause of disease that in the last fifteen years counted for frequent outbreaks, infecting both humans… 
2011
2011
A fluorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platform.
2011
2011
Discovery of the RSV Inhibitor TMC353121
2010
2010
Pharmacokinetics-Pharmacodynamics of a Respiratory Syncytial Virus Fusion Inhibitor in the Cotton Rat Model
ABSTRACT Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in infants, young… 
Highly Cited
2009
Highly Cited
2009
Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein
Six-helix bundle (6HB) formation is an essential step for many viruses that rely on a class I fusion protein to enter a target… 
Review
2009
Review
2009
Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection.
Human respiratory syncytial virus (hRSV) is a significant cause of respiratory illness in at-risk pediatric patients… 
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