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TLR7 Agonist ANA773 Tosylate

Known as: ANA773 Tosylate, Toll-Like Receptor 7 Agonist ANA773 Tosylate 
The tosylate salt form of ANA773, a Toll-Like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration… Expand
National Institutes of Health

Papers overview

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2019
2019
Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist.
Naldemedine tosylate, a peripherally acting μ-opioid receptor antagonist, is indicated for treatment of opioid induced… Expand
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2014
2014
Results from clinical trials of a selective ionotropic glutamate receptor 5 (iGluR5) antagonist, LY5454694 tosylate, in 2 chronic pain conditions
Summary No proof‐of‐principle for iGluR5 antagonism as a chronic pain treatment was demonstrated in 2 studies of osteoarthritis… Expand
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2013
2013
Development and validation of a sensitive LC-MS/MS assay for the simultaneous quantification of allitinib and its two metabolites in human plasma.
Allitinib, also known as AST1306, is a novel irreversible inhibitor of the epidermal growth factor receptors 1 and 2. Allitinib… Expand
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2011
2011
Phase I open-label, dose-escalation study of ANA773 tosylate, an oral prodrug of a toll-like receptor-7 agonist, in patients with advanced solid tumors.
2524 Background: ANA773 is an oral prodrug of a small molecule, TLR7-selective agonist which has demonstrated pharmacological… Expand
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2007
2007
The effect of dose schedule on the pharmacodynamic response to ANA773 tosylate, a prodrug of a toll-like receptor 7 specific-agonist
C235 The immune response elicited by TLR7 agonism is believed to have potential benefit in the treatment of cancer. ANA773… Expand
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