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TLR7 Agonist ANA773 Tosylate

Known as: ANA773 Tosylate, Toll-Like Receptor 7 Agonist ANA773 Tosylate 
The tosylate salt form of ANA773, a Toll-Like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist.
Naldemedine tosylate, a peripherally acting μ-opioid receptor antagonist, is indicated for treatment of opioid induced… Expand
2014
2014
Results from clinical trials of a selective ionotropic glutamate receptor 5 (iGluR5) antagonist, LY5454694 tosylate, in 2 chronic pain conditions
Summary No proof‐of‐principle for iGluR5 antagonism as a chronic pain treatment was demonstrated in 2 studies of osteoarthritis… Expand
2013
2013
Development and validation of a sensitive LC-MS/MS assay for the simultaneous quantification of allitinib and its two metabolites in human plasma.
Allitinib, also known as AST1306, is a novel irreversible inhibitor of the epidermal growth factor receptors 1 and 2. Allitinib… Expand
2011
2011
Phase I open-label, dose-escalation study of ANA773 tosylate, an oral prodrug of a toll-like receptor-7 agonist, in patients with advanced solid tumors.
2524 Background: ANA773 is an oral prodrug of a small molecule, TLR7-selective agonist which has demonstrated pharmacological… Expand
2007
2007
The effect of dose schedule on the pharmacodynamic response to ANA773 tosylate, a prodrug of a toll-like receptor 7 specific-agonist
C235 The immune response elicited by TLR7 agonism is believed to have potential benefit in the treatment of cancer. ANA773… Expand
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