TIGAR gene

Known as: TP53 induced glycolysis regulatory phosphatase, TIGAR, C12ORF5 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2018
051020042018

Papers overview

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2013
2013
Regulation of metabolic pathways plays an important role in controlling cell growth, proliferation, and survival. TIGAR acts as a… (More)
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2012
2012
Inhibition of tumor suppressor p53 is cardioprotective against ischemic injury and provides resistance to subsequent cardiac… (More)
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2012
2012
Altered metabolism in tumor cells is increasingly recognized as a core component of the neoplastic phenotype. Because p53 has… (More)
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2012
2012
The MUC1-C oncoprotein is aberrantly expressed in most multiple myeloma cells. However, the functional significance of MUC1-C… (More)
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2011
2011
c-Met represents an important emerging therapeutic target in cancer. In this study, we demonstrate the mechanism by which c-Met… (More)
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2011
2011
BACKGROUND AND PURPOSE The TP53 induced glycolysis and apoptosis regulator (TIGAR) functions to lower fructose-2,6-bisphosphate… (More)
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2010
2010
Bioenergetic homeostasis is altered in heart failure and may play an important role in pathogenesis. p53 has been implicated in… (More)
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Highly Cited
2009
Highly Cited
2009
The p53-inducible TIGAR protein functions as a fructose-2,6-bisphosphatase, promoting the pentose phosphate pathway and helping… (More)
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2009
2009
Activation of the p53 tumor suppressor by cellular stress leads to variable responses ranging from growth inhibition to apoptosis… (More)
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Highly Cited
2006
Highly Cited
2006
The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle… (More)
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