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THOP1 gene

Known as: THIMET OLIGOPEPTIDASE 1, THOP1, TOP 
National Institutes of Health

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thimet oligopeptidase

Papers overview

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Highly Cited
2018
Highly Cited
2018
Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases
Purpose Current evidence suggests that retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy… 
Highly Cited
2013
Highly Cited
2013
Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts
Significance Import of proteins to mitochondria and chloroplasts is essential for organelle biogenesis and organism survival… 
Highly Cited
2009
Highly Cited
2009
Analysis of Intracellular Substrates and Products of Thimet Oligopeptidase in Human Embryonic Kidney 293 Cells*
Thimet oligopeptidase (EC 3.4.24.15; EP24.15) is an intracellular enzyme that has been proposed to metabolize peptides within… 
2008
2008
Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Aβ toxicity
2003
2003
Involvement of surface cysteines in activity and multimer formation of thimet oligopeptidase.
Thimet oligopeptidase is a metalloenzyme involved in regulating neuropeptide processing. Three cysteine residues (246, 248, 253… 
1999
1999
Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain
Highly Cited
1999
Highly Cited
1999
Thimet oligopeptidase and the stability of MHC class I epitopes in macrophage cytosol.
In this study we investigated the fate of a class of proteasome-generated oligopeptides, exposing them to the crude cytosol of… 
1994
1994
Cloning, amino acid sequence and tissue distribution of porcine thimet oligopeptidase. A comparison with soluble angiotensin-binding protein.
We have previously determined the amino acid sequence of porcine soluble angiotensin-binding protein (sABP) by cDNA cloning and… 
Highly Cited
1993
Highly Cited
1993
Human thimet oligopeptidase.
We have purified human thimet oligopeptidase to homogeneity from erythrocytes, and compared it with the enzyme from rat testis… 
Review
1993
Review
1993
Thimet oligopeptidase--a review of a thiol dependent metallo-endopeptidase also known as Pz-peptidase endopeptidase 24.15 and endo-oligopeptidase.
Thimet oligopeptidase (EC 3.4.24.15) is a thiol-dependent metallo-endopeptidase also known as Pz-peptidase, collagenase-like… 
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