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TGN 020

Known as: TGN-020, TGN020 
National Institutes of Health

Papers overview

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2020
2020
Effects of an Aquaporin 4 Inhibitor, TGN-020, on Murine Diabetic Retina
Purpose: To investigate the effect of a selective aquaporin 4 (AQP4) inhibitor, 2-(nicotinamide)-1,3,4-thiadiazole (TGN-020), on… 
2020
2020
Contrast-enhanced magnetic resonance imaging evidence for the role of astrocytic aquaporin-4 water channels in glymphatic influx and interstitial solute transport.
2019
2019
TGN‐020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats
2018
2018
Isoflurane post-conditioning down-regulates expression of aquaporin 4 in rats with cerebral ischemia/reperfusion injury and is possibly related to bone morphogenetic protein 4/Smad1/5/8 signaling…
2018
2018
Correlation of TGN-020 with the analgesic effects via ERK pathway activation after chronic constriction injury
Extracellular regulated protein kinase (ERK) pathway activation in astrocytes and neurons has been reported to be critical for… 
2017
2017
The pathway of subarachnoid CSF moving into the spinal parenchyma and the role of astrocytic aquaporin‐4 in this process
2017
2017
Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior
Methamphetamine (METH) abuse/misuse is a worldwide problem, and despite extensive characterization of its neurotoxicity over the… 
2016
2016
Negative impact of AQP-4 channel inhibition on survival of retinal ganglion cells and glutamate metabolism after crushing optic nerve.
2013
2013
Aquaporin‐4 Positron Emission Tomography Imaging of the Human Brain: First Report
Aquaporin 4 (AQP‐4) is the most abundant aquaporin isoform in the brain. Alterations in its expression and distribution have been… 
Highly Cited
2013
Highly Cited
2013
Inhibition of aquaporin-4 significantly increases regional cerebral blood flow
The effects of the aquaporin-4 (AQP-4) inhibitor TGN-020 on regional cerebral blood flow (rCBF) was examined in wild-type (WT… 
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