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TFR2 gene

Known as: TFRC2, Transferrin Receptor 2 Gene, TRANSFERRIN RECEPTOR 2 
This gene plays a role in iron metabolism.
National Institutes of Health

Related topics

Related topics

10 relations
ErythropoiesisHEMOCHROMATOSIS, TYPE 3Homo sapiensIonophore activity

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TFR2 wt Allele

Papers overview

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2011
2011
Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2.
The induction of the iron-regulatory peptide hepcidin by proinflammatory cytokines is thought to result in the withholding of… 
2011
2011
Hereditary hemochromatosis: mutations in genes involved in iron homeostasis in Brazilian patients.
Highly Cited
2010
Highly Cited
2010
Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent…
Background Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of… 
Highly Cited
2009
Highly Cited
2009
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.
Highly Cited
2008
Highly Cited
2008
Iron and inflammation: cross-talk between pathways regulating hepcidin
Highly Cited
2006
Highly Cited
2006
Hereditary Hemochromatosis Protein, HFE, Interaction with Transferrin Receptor 2 Suggests a Molecular Mechanism for Mammalian Iron Sensing*
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human… 
Review
2005
Review
2005
Non-HFE Hemochromatosis
HFE insu strictu TfR2 HJV HAMP HFE HFE HFE 
Review
2003
Review
2003
Transferrin receptor 2: a new molecule in iron metabolism.
Highly Cited
2002
Highly Cited
2002
Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation.
Hereditary hemochromatosis (HH) is classically associated with a Cys282Tyr (C282Y) mutation of the HFE gene. Non-C282Y HH is a… 
Highly Cited
2002
Highly Cited
2002
Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene.
BACKGROUND & AIMS Although most patients with hereditary hemochromatosis are homozygous for a single mutation of the HFE gene on… 
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