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TFR2 gene

Known as: TFRC2, Transferrin Receptor 2 Gene, TRANSFERRIN RECEPTOR 2 
This gene plays a role in iron metabolism.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
In response to iron loading, hepcidin synthesis is homeostatically increased to limit further absorption of dietary iron and its… Expand
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Review
2010
Review
2010
In the late 1800s, hemochromatosis was considered an odd autoptic finding. More than a century later, it was finally recognized… Expand
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Highly Cited
2009
Highly Cited
2009
The mechanisms that allow the body to sense iron levels in order to maintain iron homeostasis are unknown. Patients with the most… Expand
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Highly Cited
2007
Highly Cited
2007
Mutations in the transmembrane glycoproteins transferrin receptor 2 (TfR2) and HFE are associated with hereditary hemochromatosis… Expand
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Highly Cited
2006
Highly Cited
2006
Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic… Expand
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Highly Cited
2006
Highly Cited
2006
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human… Expand
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Highly Cited
2005
Highly Cited
2005
Background: Transferrin receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in humans… Expand
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Highly Cited
2004
Highly Cited
2004
The antimicrobial peptide hepcidin appears to play a central role in the regulation of iron homeostasis. In intact animals, iron… Expand
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Highly Cited
2002
Highly Cited
2002
Hereditary hemochromatosis (HH) is classically associated with a Cys282Tyr (C282Y) mutation of the HFE gene. Non-C282Y HH is a… Expand
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Highly Cited
2001
Highly Cited
2001
Complementary and genomic DNA for the murine transferrin receptor 2 (TfR2) were cloned and mapped to chromosome 5. Northern blot… Expand
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