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TFF2 wt Allele

Known as: SP, Spasmolytic Protein 1 Gene, SML1 
Human TFF2 wild-type allele is located in the vicinity of 21q22.3 and is approximately 5 kb in length. This allele, which encodes trefoil factor 2… 
National Institutes of Health

Related topics

Related topics

3 relations
21q22.3DigestionGastric Acid Secretion Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Regulation of Small Mitochondrial DNA Replicative Advantage by Ribonucleotide Reductase in Saccharomyces cerevisiae
Small mitochondrial genomes can behave as selfish elements by displacing wild-type genomes regardless of their detriment to the… 
2015
2015
S phase block following MEC1ATR inactivation occurs without severe dNTP depletion
ABSTRACT Inactivation of Mec1, the budding yeast ATR, results in a permanent S phase arrest followed by chromosome breakage and… 
2012
2012
Cadmium inhibits the protein degradation of Sml1 by inhibiting the phosphorylation of Sml1 in Saccharomyces cerevisiae.
2007
2007
Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1
Ribonucleotide reductase maintains cellular deoxyribonucleotide pools and is thus tightly regulated during the cell cycle to… 
Highly Cited
2005
Highly Cited
2005
The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae.
How mitochondrial DNA (mtDNA) copy number is determined and modulated according to cellular demands is largely unknown. Our… 
2005
2005
Inactivation of Ku-Mediated End Joining Suppresses mec1Δ Lethality by Depleting the Ribonucleotide Reductase Inhibitor Sml1 through a Pathway Controlled by Tel1 Kinase and the Mre11 Complex
ABSTRACT RAD53 and MEC1 are essential Saccharomyces cerevisiae genes required for the DNA replication and DNA damage checkpoint… 
2004
2004
Identification of Phosphorylation Sites on the Yeast Ribonucleotide Reductase Inhibitor Sml1*
Sml1 is a small protein in Saccharomyces cerevisiae which inhibits the activity of ribonucleotide reductase (RNR). RNR catalyzes… 
Highly Cited
2001
Highly Cited
2001
The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage
The evolutionarily conserved protein kinases Mec1 and Rad53 are required for checkpoint response and growth. Here we show that… 
2000
2000
Damage response and dNTP regulation: the interaction between ribonucleotide reductase and its inhibitor, Sml1.
1992
1992
The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q 22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2.
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