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TERT Deficiency

A condition of decreased or absent presence of telomerase reverse transcriptase. Deficiency of this protein is associated with autosomal dominant… Expand
National Institutes of Health

Papers overview

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2019
2019
Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescence
Mutations in the genes encoding telomerase reverse transcriptase (TERT) and telomerase's RNA components as well as shortened… Expand
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2019
2019
Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury
Introduction: Elevated levels of mitochondrial reactive oxygen species (ROS) contribute to the development of numerous… Expand
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2017
2017
Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes
Objective— Aberrant proliferation of smooth muscle cells (SMC) in response to injury induces pathological vascular remodeling… Expand
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2016
2016
Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert−/− mice
The role of telomerase reverse transcriptase (TERT) has been extensively investigated in the contexts of aging and cancer… Expand
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2015
2015
Conditional Knockout of Telomerase Reverse Transcriptase in Mesenchymal Cells Impairs Mouse Pulmonary Fibrosis
Telomerase is typically expressed in cellular populations capable of extended replication, such as germ cells, tumor cells, and… Expand
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Highly Cited
2011
Highly Cited
2011
Telomerase Activation in Atherosclerosis and Induction of Telomerase Reverse Transcriptase Expression by Inflammatory Stimuli in Macrophages
Objective—Telomerase serves as a critical regulator of tissue renewal. Although telomerase activity is inducible in response to… Expand
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2011
2011
Telomerase Deficiency in Bone Marrow–Derived Cells Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm Formation
Objective—Abdominal aortic aneurysms (AAA) are an age-related vascular disease and an important cause of morbidity and mortality… Expand
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2010
2010
Deficiency of telomerase activity aggravates the blood–brain barrier disruption and neuroinflammatory responses in a model of experimental stroke
Epidemiology and genetic studies indicate that patients with telomere length shorter than average are at higher risk of dying… Expand
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