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TECTA wt Allele

Known as: DFNB21, DFNA8, Tectorin, Alpha Gene 
Human TECTA wild-type allele is located within 11q22-q24 and is approximately 90 kb in length. This allele, which encodes alpha-tectorin protein, is… 
National Institutes of Health

Related topics

Related topics

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Cell AdhesionCell MovementHearingMorphogenesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Diverse pattern of gap junction beta-2 and gap junction beta-4 genes mutations and lack of contribution of DFNB21, DFNB24, DFNB29, and DFNB42 loci in autosomal recessive nonsyndromic hearing loss…
Background: We aimed to determine the contribution of four DFNB loci and mutation analysis of gap junction beta-2 (GJB2) and GJB4… 
2016
2016
Genetic Linkage Analysis of DFNB3, DFNB9 and DFNB21 Loci in GJB2 Negative Families with Autosomal Recessive Non-syndromic Hearing Loss
Background: Autosomal recessive non-syndromic hearing loss (ARNSHL) is the most common hereditary form of deafness, and exhibits… 
2009
2009
Contribution of GJB2 mutations and Four common DFNB loci in autosomal recessive non-syndromic hearing impairment in Markazi and Qom provinces of Iran
This study aimed to investigate the contribution of four common DFNB (“DFN” for deafness and “B” for autosomal resessive locus… 
Highly Cited
2004
Highly Cited
2004
A Genotype-Phenotype Correlation with Gender-Effect for Hearing Impairment Caused by TECTA Mutations
Background: Alpha-tectorin is a noncollagenous component of the tectorial membrane which plays an essential role in auditory… 
Highly Cited
2003
Highly Cited
2003
Distinctive audiometric profile associated with DFNB21 alleles of TECTA
enetic factors are thought to account for approximately one half of cases of childhood hearing loss, the majority of which is non… 
2000
2000
Audiometric characterization of a family with digenic autosomal, dominant, progressive sensorineural hearing loss.
In this study, a non-syndromic progressive bilateral high frequency hearing loss is described in a family with 141 identified… 
Highly Cited
1999
Highly Cited
1999
Mutation in the zonadhesin-like domain of α-tectorin associated with autosomal dominant non-syndromic hearing loss
A gene responsible for autosomal dominant non-syndromic hearing impairment in two families (DFNA8 and DFNA12) has recently been… 
Highly Cited
1999
Highly Cited
1999
Mutations in the human α-tectorin gene cause autosomal dominant non-syndromic hearing impairment
Kristien Verhoeven et al. Nature Genet. 19, 60–62 (1998). The nucleotide numbering of the mouse gene was used for the human… 
1998
1998
Autosomal-dominant, prelingual, nonprogressive sensorineural hearing loss: localization of the gene (DFNA8) to chromosome 11q by linkage in an Austrian family
A four-generation family suffering from an autosomal-dominant, congenital, nonprogressive, nonsyndromic hearing loss was found in… 
1998
1998
Identifying the genes of hearing, deafness, and dysequilibrium.
Purely scientific interests provide justification for efforts to understand the mechanisms of the inner ear. The cochlea is… 
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