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TECTA wt Allele

Known as: DFNB21, DFNA8, Tectorin, Alpha Gene 
Human TECTA wild-type allele is located within 11q22-q24 and is approximately 90 kb in length. This allele, which encodes alpha-tectorin protein, is… Expand
National Institutes of Health

Related topics

Related topics

8 relations
Cell AdhesionCell MovementHearingMorphogenesis
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
A Genotype-Phenotype Correlation with Gender-Effect for Hearing Impairment Caused by TECTA Mutations
Background: Alpha-tectorin is a noncollagenous component of the tectorial membrane which plays an essential role in auditory… Expand
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2003
2003
Distinctive audiometric profile associated with DFNB21 alleles of TECTA
enetic factors are thought to account for approximately one half of cases of childhood hearing loss, the majority of which is non… Expand
Highly Cited
1999
Highly Cited
1999
Mutation in the zonadhesin-like domain of α-tectorin associated with autosomal dominant non-syndromic hearing loss
A gene responsible for autosomal dominant non-syndromic hearing impairment in two families (DFNA8 and DFNA12) has recently been… Expand
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1999
1999
Alpha-tectorin involvement in hearing disabilities: one gene – two phenotypes
Abstract. The human α-tectorin (TECTA) gene has recently been cloned and proposed to be involved in autosomal dominant non… Expand
1999
1999
Mutations in the human α-tectorin gene cause autosomal dominant non-syndromic hearing impairment
Kristien Verhoeven et al. Nature Genet. 19, 60–62 (1998). The nucleotide numbering of the mouse gene was used for the human… Expand
Highly Cited
1998
Highly Cited
1998
Mutations in the human α-tectorin gene cause autosomal dominant non-syndromic hearing impairment
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory… Expand
Highly Cited
1998
Highly Cited
1998
Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment.
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory… Expand
Highly Cited
1998
Highly Cited
1998
Evidence for digenic inheritance of nonsyndromic hereditary hearing loss in a Swedish family.
We investigated a Swedish family with nonsyndromic progressive bilateral sensorineural hearing loss. Thirteen candidate loci for… Expand
1998
1998
Autosomal-dominant, prelingual, nonprogressive sensorineural hearing loss: localization of the gene (DFNA8) to chromosome 11q by linkage in an Austrian family
A four-generation family suffering from an autosomal-dominant, congenital, nonprogressive, nonsyndromic hearing loss was found in… Expand
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Highly Cited
1997
Highly Cited
1997
A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24.
We performed linkage analysis in a Belgian family with autosomal dominant midfrequency hearing loss, which has a prelingual onset… Expand
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