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TD-1211

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Investigational opioid antagonists for treating opioid-induced bowel dysfunction
ABSTRACT Introduction: Opioids have been highlighted for their role in pain relief among cancer and non-cancer patients. Novel… 
2013
2013
The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist
The clinical efficacy of opioid receptor antagonists for the treatment of opioid-induced constipation (OIC) is established… 
2013
2013
The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity
The in vivo preclinical pharmacodynamic profile of TD-1211, a selective opioid receptor antagonist currently under development… 
2011
2011
TD-1211 Demonstrates Constipation-relieving Effects, Including Decrease in Rescue Laxative Use, in Patients with Opioid-Induced Constipation: 2011 ACG Presidential Poster: 1341
No serious adverse events (SAEs) reported Opioid analgesics such as morphine continue to play a critical role in chronic cancer… 
2010
2010
TD-1211, a potent and peripherally-selective μ-opioid receptor antagonist
The opioid receptor affinity (expressed as a pKi value) of test agents was determined using radioligand binding assays with [3H… 
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