TAZ, IVS1DS, G-C, +5

Insulin resistance is a major factor in obesity-linked type 2 diabetes. PPARγ is a master regulator of adipogenesis, and small… Expand

The Hippo pathway has emerged as a key signaling pathway that regulates a broad range of biological functions, and dysregulation… Expand

Our previously published study demonstrated that mammalian target of rapamycin complex 2 (mTORC2) signaling mediates TGFβ1… Expand

ABSTRACT Introduction: The Hippo pathway represents a new and intriguing opportunity for the treatment of cancer. Activation or… Expand

YAP (yes-associated protein) and TAZ are oncogenic transcriptional co-activators downstream of the Hippo tumor-suppressor pathway… Expand

The Hippo pathway plays a crucial role in growth control, proliferation and tumor suppression. Activity of the signaling pathway… Expand

To investigate the role of Hippo pathway signaling during vertebrate development transgenic zebrafish lines were generated and… Expand

The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian… Expand

Barth's syndrome (BTHS) is an X-linked mitochondrial disease that is due to a mutation in the Tafazzin (TAZ) gene. Based on… Expand

The Hippo pathway regulates organ size by controlling both cell proliferation and apoptosis. TAZ functions as a transcriptional… Expand