TAZ, IVS1DS, G-C, +5

The Hippo effector YAP has recently been identified as a potent driver of embryonal rhabdomyosarcoma (ERMS). Most reports suggest… (More)

Insulin resistance (IR) is an important mechanism of pathogenesis of endometrial cancer (EC) and explains the pathogenic… (More)

YAP (yes-associated protein) and TAZ are oncogenic transcriptional co-activators downstream of the Hippo tumor-suppressor pathway… (More)

The Hippo pathway plays a crucial role in growth control, proliferation and tumor suppression. Activity of the signaling pathway… (More)

The molecular origins of fibrosis affecting multiple tissue beds remain incompletely defined. Previously, we delineated the… (More)

The transcriptional co-activator with PDZ-binding motif (TAZ) is a downstream effector of the Hippo tumor suppressor pathway… (More)

To investigate the role of Hippo pathway signaling during vertebrate development transgenic zebrafish lines were generated and… (More)

The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian… (More)

The Hippo pathway regulates organ size by controlling both cell proliferation and apoptosis. TAZ functions as a transcriptional… (More)

Barth's syndrome (BTHS) is an X-linked mitochondrial disease that is due to a mutation in the Tafazzin (TAZ) gene. Based on… (More)