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TAZ, IVS1DS, G-C, +5

National Institutes of Health

Related topics

Related topics

1 relation
3-Methylglutaconic aciduria type 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance.
Insulin resistance is a major factor in obesity-linked type 2 diabetes. PPARγ is a master regulator of adipogenesis, and small… Expand
2019
2019
Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors
The Hippo pathway has emerged as a key signaling pathway that regulates a broad range of biological functions, and dysregulation… Expand
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Review
2018
Review
2018
Hippo pathway inhibition by blocking the YAP/TAZ–TEAD interface: a patent review
ABSTRACT Introduction: The Hippo pathway represents a new and intriguing opportunity for the treatment of cancer. Activation or… Expand
2018
2018
Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis
Our previously published study demonstrated that mammalian target of rapamycin complex 2 (mTORC2) signaling mediates TGFβ1… Expand
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Highly Cited
2015
Highly Cited
2015
Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.
YAP (yes-associated protein) and TAZ are oncogenic transcriptional co-activators downstream of the Hippo tumor-suppressor pathway… Expand
Highly Cited
2015
Highly Cited
2015
Crosstalk between Hippo and TGFβ: Subcellular Localization of YAP/TAZ/Smad Complexes.
The Hippo pathway plays a crucial role in growth control, proliferation and tumor suppression. Activity of the signaling pathway… Expand
Highly Cited
2015
Highly Cited
2015
A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions
The molecular origins of fibrosis affecting multiple tissue beds remain incompletely defined. Previously, we delineated the… Expand
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Highly Cited
2012
Highly Cited
2012
Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.
The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian… Expand
Highly Cited
2011
Highly Cited
2011
Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency.
Barth's syndrome (BTHS) is an X-linked mitochondrial disease that is due to a mutation in the Tafazzin (TAZ) gene. Based on… Expand
Highly Cited
2010
Highly Cited
2010
PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ*
The Hippo pathway regulates organ size by controlling both cell proliferation and apoptosis. TAZ functions as a transcriptional… Expand
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