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TAK-448

National Institutes of Health

Papers overview

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2019
2019
The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats
2-(N-acetyl-D-tyrosyl-trans-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl) hydrazinocarbonyl-L-leucyl-Nω-methyl-L… 
2018
2018
Investigation of disposition for TAK-448, a synthetic peptide of kisspeptin analog, in rats and dogs using the radiolabeled TAK-448 suitable for pharmacokinetic study
Abstract Disposition of 2-(N-acetyl-d-tyrosyl-trans-4-hydroxy-l-prolyl-l-asparaginyl-l-threonyl-l-phenylalanyl) hydrazinocarbonyl… 
2018
2018
Evaluation of pharmacokinetics/pharmacodynamics and efficacy of one‐month depots of TAK‐448 and TAK‐683, investigational kisspeptin analogs, in male rats and an androgen‐dependent prostate cancer…
2018
2018
Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK‐448, in quantitatively evaluating anti‐tumor growth effect in the rat VCaP androgen‐sensitive prostate…
2018
2018
Additive effect of simultaneous continuous administration of degarelix and TAK‐448 on LH suppression in a castrated rat model
2016
2016
Stimulatory effects of the long-acting kisspeptin analogue TAK-448 on serum testosterone in men with type 2 diabetes and hypogonadotropic hypogonadism
2010
2010
251 Potent and efficient testosterone suppression by chronic administration of novel metastin analogues, TAK-448 and TAK-683, in male rats
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