TAK-441

Known as: 6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, Smoothened Antagonist TAK-441 
An orally bioavailable pyrrolopyridine derivative and Smoothened (Smo) antagonist with potential antineoplastic activity. Smo antagonist TAK-441… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2017
02420112017

Papers overview

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2017
2017
Despite the substantial benefit of androgen deprivation therapy (ADT) for metastatic prostate cancer, patients often progress to… (More)
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2016
2016
The Hedgehog (HH) pathway has been linked to the formation of basal cell carcinoma (BCC), medulloblastoma, and other cancers. The… (More)
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2015
2015
PURPOSE This first-in-human study assessed safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary clinical… (More)
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Review
2015
Review
2015
The Hedgehog (Hh) signaling pathway is critical for embryonic development. In adult tissues, Hh signaling is relatively quiescent… (More)
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2014
2014
Hedgehog signaling is a driving force in medulloblastoma and basal cell carcinoma (BCC), making it an attractive therapeutic… (More)
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2014
2014
Inappropriate activation of the Hh signaling pathway has been implicated in the development of several types of cancers including… (More)
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2013
2013
Hedgehog (Hh) signaling is a highly conserved intercellular and intracellular communication mechanism that governs organogenesis… (More)
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2013
2013
6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H… (More)
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2012
2012
We recently reported the discovery of the novel pyrrolo[3,2-c]quinoline-4-one derivative 1 as a potent inhibitor of Hedgehog (Hh… (More)
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Review
2011
Review
2011
A number of therapies that target components of the Hedgehog signaling pathway currently are in clinical trials. The specific… (More)
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