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TAK-441
Known as:
6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
, Smoothened Antagonist TAK-441
An orally bioavailable pyrrolopyridine derivative and Smoothened (Smo) antagonist with potential antineoplastic activity. Smo antagonist TAK-441…
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National Institutes of Health
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3 relations
NCIt Antineoplastic Agent Terminology
Broader (2)
Pyridines
Pyrroles
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2015
2015
Dose-Escalation Trial of the Oral Investigational Hedgehog Signaling Pathway Inhibitor TAK-441 in Patients with Advanced Solid Tumors
J. Goldman
,
S. Eckhardt
,
+12 authors
D. Bowles
2015
Corpus ID: 641138
Purpose: This first-in-human study assessed safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary clinical…
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