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TACSTD2 protein, human

Known as: Gastrointestinal Tumor-Associated Antigen GA7331, TROP2 protein, human, TROP-2 
Tumor-associated calcium signal transducer 2 (323 aa, ~36 kDa) is encoded by the human TACSTD2 gene. This protein is involved in calcium-dependent… 
National Institutes of Health

Related topics

Related topics

19 relations

Broader (2)

Antigens, NeoplasmCell Adhesion Molecules
Calcium SignalingEPCAM geneEPCAM wt AlleleEdrecolomab

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The Diagnostic Validity of TROP-2 in Recognizing Papillary Thyroid Carcinoma
Background: Thyroid cancer is currently the third fastest rising cancer diagnosis in the United States and represents 80.3% of… 
2016
2016
Selective killing of human cancer cells by targeting a fusion mRNA between CYCLIN D1 and TROP2.
e14569 Background: Trop-2 is a calcium signal transducer and a stem cell marker. Trop-2 is widely overexpressed by human cancers… 
2016
2016
Abstract 463: Immunohistochemical study of TROP-2 protein expression in thyroid lesions
Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Introduction Tumor-associated calcium signal… 
2015
2015
Therapy of advanced metastatic lung cancer with an anti-Trop-2-SN-38 antibody-drug conjugate (ADC), sacituzumab govitecan (IMMU-132): Phase I/II clinical experience.
2504 Background: Sacituzumab govitecan (IMMU-132) is a new ADC comprising SN-38, the active metabolite of the topoisomerase… 
2015
2015
Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts
Enhancement Program grant with the Pennsylvania Department of Health (H.R.); the Department specifically disclaims responsibility… 
2013
2013
Abstract C67: Safety, efficacy, and pharmacokinetics of a new humanized anti-Trop-2 antibody-SN-38 conjugate (IMMU-132) for the treatment of diverse epithelial cancers: Phase I clinical experience.
Trop-2 (trophoblastic antigen-2; aka EGP-1, GA733-1) is a surface glycoprotein differentially expressed on a variety of malignant… 
2012
2012
Co-localisation of advanced glycation end products and d-β-aspartic acid-containing proteins in gelatinous drop-like corneal dystrophy
Purpose Gelatinous drop-like corneal dystrophy (GDLD), also known as familial subepithelial corneal amyloidosis, is an autosomal… 
2012
2012
89Zr-Desferrioxamine-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody
2010
2010
Abstract 5346: A novel immunotoxin comprising quadruple RNase tethered to an internalizing anti-TROP-2 humanized MAb shows potent cytotoxicity against diverse solid tumorsin vitro
Ribonucleases (RNase) are potential anti-tumor agents, and their potency can be enhanced by recombinant fusion or chemical… 
2010
2010
Combination 90Y-hPAM4 radioimmunotherapy (RAIT) and anti-epithelial glycoprotein-1 (EGP-1)-SN-38 antibody-drug conjugate (ADC) improves pancreatic cancer therapy without increasing toxicity
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