Structure of alpha Cell of islet

Known as: Cells, Glucagon-Secreting, Alpha cell of pancreatic islet, Alpha cell 
A type of pancreatic cell representing about 5-20% of the islet cells. Alpha cells secrete GLUCAGON.
National Institutes of Health

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12 relations
Acidophil cell of pars distalis of adenohypophysisEndocrine systemEpitheliumGastrointestinal system
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Papers overview

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Highly Cited
2015
Highly Cited
2015
Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
Type 2 diabetes (T2D) is characterized by chronic hyperglycemia resulting from a deficiency in insulin signaling, because of… (More)
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Highly Cited
2011
Highly Cited
2011
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of interleukin-6 (IL-6). Glucagon-like… (More)
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Highly Cited
2011
Highly Cited
2011
Pancreatic alpha cell mass in European subjects with type 2 diabetes
Type 2 diabetes is a bi-hormonal disease characterised by relative hypoinsulinaemia and hyperglucagonaemia with elevated blood… (More)
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Highly Cited
2009
Highly Cited
2009
Insulin signaling in alpha cells modulates glucagon secretion in vivo.
Glucagon plays an important role in glucose homeostasis by regulating hepatic glucose output in both normo- and hypoglycemic… (More)
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Highly Cited
2006
Highly Cited
2006
Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans.
BACKGROUND Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin… (More)
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Review
2005
Review
2005
Alpha cell function in health and disease: influence of glucagon-like peptide-1
Although there is abundant evidence that hyperglucagonaemia plays a key role in the development of hyperglycaemia in type 2… (More)
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Highly Cited
2003
Highly Cited
2003
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.
Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic alpha cells in response to low blood glucose. To… (More)
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Highly Cited
1984
Highly Cited
1984
Insulin within islets is a physiologic glucagon release inhibitor.
To determine if glucagon secretion is under physiological control of intra-islet insulin, pancreata from normal rats were… (More)
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Highly Cited
1973
Highly Cited
1973
Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect.
Despite excessive glucagon responses to infusion of arginine, plasma glucagon did not rise in six juvenile-type diabetics during… (More)
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Highly Cited
1970
Highly Cited
1970
Studies of pancreatic alpha cell function in normal and diabetic subjects.
The development of a glucagon radioimmunoassay with a relatively high degree of specificity for pancreatic glucagon made possible… (More)
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