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Structural Modifier

Known as: Chemical Modification, STRUCTURAL MODIFICATION 
A molecule that binds to a macromolecule and can change the structural properties of that macromolecule.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Studies on bacterial ribosomes by chemical modification approaches
Highly Cited
1999
Highly Cited
1999
Effects of chemical modification on in vitro rate and extent of food starch digestion: an attempt to discover a slowly digested starch.
Differences in glycemic and insulinemic responses to dietary starch are directly related to the rate of starch digestion… 
Review
1986
Review
1986
Enzymic aldol condensation/isomerization as a route to unusual sugar derivatives.
Preparative enzymatic synthesis of several unusual hexoketose and hexoaldose derivatives using fructose bisphosphate aldolase and… 
Highly Cited
1982
Highly Cited
1982
Synthesis of (-)-15-deoxyspergualin and (-)-spergualin-15-phosphate.
The method for chemical modification of spergualin with retention of the configuration at the C-11 has been achieved by the use… 
Highly Cited
1982
Highly Cited
1982
Guanidine hydrochloride induced unfolding of the alpha subunit of tryptophan synthase and of the two alpha proteolytic fragments: evidence for stepwise unfolding of the two alpha domains.
The relationship between the domain structure of the alpha subunit of Escherichia coli tryptophan synthase and the mechanism of… 
Review
1980
Review
1980
Physical chemical studies of the structure and function of DNA binding (helix-destabilizing) proteins.
Binding of proteins to DNA is fundamental to the mechanisms of replication, recombination and gene expression. The specific… 
Highly Cited
1976
Highly Cited
1976
Structure of gene 5 protein-oligodeoxynucleotide complexes as determined by 1H, 19F, and 31P nuclear magnetic resonance.
1H nuclear magnetic resonance (NMR) spectra at 270 MHz of gene 5 protein from bacteriophage fd and its complexes with tetra- and… 
Highly Cited
1975
Highly Cited
1975
Chemical modifications of functional residues of fd gene 5 DNA-binding protein.
The binding of gene 5 protein from bacteriophage fd to poly[d(A-T)], fdDNA, and poly(A) is accompanied by a dramatic reversal in… 
Review
1971
Review
1971
Metabolic regulation by chemical modification of enzymes.
Highly Cited
1970
Highly Cited
1970
Specific separation of cells on affinity columns.
Cell filtration is performed on affinity columns prepared by the chemical modification of large polyacrylamide beads. Affinity…