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Staphylocoagulase

An extracellular protein which specifically forms a complex with human prothrombin. This complex named staphylothrombin can clot fibrinogen without… Expand
National Institutes of Health

Related topics

Related topics

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Broader (1)

Coagulase

Papers overview

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Highly Cited
2009
Highly Cited
2009
Genetic Diversity of Staphylocoagulase Genes (coa): Insight into the Evolution of Variable Chromosomal Virulence Factors in Staphylococcus aureus
Background The production of staphylocoagulase (SC) causing the plasma coagulation is one of the important characteristics of… Expand
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Highly Cited
2006
Highly Cited
2006
Fibrinogen Substrate Recognition by Staphylocoagulase·(Pro)thrombin Complexes*
Thrombin generation and fibrinogen (Fbg) clotting are the ultimate proteolytic reactions in the blood coagulation pathway… Expand
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2004
2004
The staphylocoagulase family of zymogen activator and adhesion proteins
Abstract.Staphylocoagulase (SC) secreted by Staphylococcus aureus is a potent non-proteolytic activator of the blood coagulation… Expand
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Highly Cited
2003
Highly Cited
2003
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
Many bacterial pathogens secrete proteins that activate host trypsinogen-like enzyme precursors, most notably the proenzymes of… Expand
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Highly Cited
1992
Highly Cited
1992
Molecular typing of Staphylococcus aureus on the basis of coagulase gene polymorphisms.
Staphylocoagulase, a major phenotypic determinant of Staphylococcus aureus, exists in multiple allelic forms, in part because of… Expand
Highly Cited
1987
Highly Cited
1987
Nucleotide sequence of the staphylocoagulase gene: its unique COOH-terminal 8 tandem repeats.
The entire staphylocoagulase gene of Staphylococcus aureus strain BB was cloned on a MboI restriction endonuclease fragment… Expand
Highly Cited
1985
Highly Cited
1985
Enzymatic properties of staphylothrombin, an active molecular complex formed between staphylocoagulase and human prothrombin.
Staphylocoagulase with a molecular weight of 64,000 and subspecies ranging in molecular weight from 36,000 to 64,000 were… Expand
1985
1985
Staphylocoagulase-binding region in human prothrombin.
A staphylocoagulase-binding region in human prothrombin was studied by utilizing several fragments prepared from prothrombin by… Expand
Highly Cited
1983
Highly Cited
1983
Activation of human prothrombin by stoichiometric levels of staphylocoagulase.
The activation of human prothrombin by the bacterial protein staphylocoagulase proceeds via the formation of a very stable… Expand
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Highly Cited
1975
Highly Cited
1975
Activation of a pro-enzyme by a stoichiometric reaction with another protein. The reaction between prothrombin and staphylocoagulase.
The reaction between prothrombin and staphylocoagulase was investigated and the following conclusions were drawn: (a) Optimal… Expand
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