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Staphylocoagulase

An extracellular protein which specifically forms a complex with human prothrombin. This complex named staphylothrombin can clot fibrinogen without… Expand
National Institutes of Health

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Coagulase

Papers overview

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Highly Cited
2011
Highly Cited
2011
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
Coagulase-positive Staphylococcus aureus (S. aureus) is the major causal pathogen of acute endocarditis, a rapidly progressing… Expand
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Highly Cited
2010
Highly Cited
2010
Staphylococcus aureus RNAIII Binds to Two Distant Regions of coa mRNA to Arrest Translation and Promote mRNA Degradation
Staphylococcus aureus RNAIII is the intracellular effector of the quorum sensing system that temporally controls a large number… Expand
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2009
2009
Genetic Diversity of Staphylocoagulase Genes (coa): Insight into the Evolution of Variable Chromosomal Virulence Factors in Staphylococcus aureus
BACKGROUND The production of staphylocoagulase (SC) causing the plasma coagulation is one of the important characteristics of… Expand
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2006
2006
Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexes.
Thrombin generation and fibrinogen (Fbg) clotting are the ultimate proteolytic reactions in the blood coagulation pathway… Expand
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2004
2004
The staphylocoagulase family of zymogen activator and adhesion proteins
Abstract.Staphylocoagulase (SC) secreted by Staphylococcus aureus is a potent non-proteolytic activator of the blood coagulation… Expand
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Highly Cited
2003
Highly Cited
2003
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
Many bacterial pathogens secrete proteins that activate host trypsinogen-like enzyme precursors, most notably the proenzymes of… Expand
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Highly Cited
1999
Highly Cited
1999
Recommended minimal standards for description of new staphylococcal species. Subcommittee on the taxonomy of staphylococci and streptococci of the International Committee on Systematic Bacteriology.
In accordance with Recommendation 30b of the International Code of Nomenclature of Bacteria, minimal standards are proposed for… Expand
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Highly Cited
1992
Highly Cited
1992
Molecular typing of Staphylococcus aureus on the basis of coagulase gene polymorphisms.
Staphylocoagulase, a major phenotypic determinant of Staphylococcus aureus, exists in multiple allelic forms, in part because of… Expand
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1985
1985
Enzymatic properties of staphylothrombin, an active molecular complex formed between staphylocoagulase and human prothrombin.
Staphylocoagulase with a molecular weight of 64,000 and subspecies ranging in molecular weight from 36,000 to 64,000 were… Expand
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1983
1983
Activation of human prothrombin by stoichiometric levels of staphylocoagulase.
The activation of human prothrombin by the bacterial protein staphylocoagulase proceeds via the formation of a very stable… Expand
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