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Sperm Adhesion Molecule 1

Known as: sperm PH-20 antigen, membrane protein PH-20, sperm, Sperm surface protein PH-20 
Hyaluronidase PH-20 (509 aa, ~58 kDa) is encoded by the human SPAM1 gene. This protein plays a role in sperm-egg adhesion, hyaluronic acid catabolism… 
National Institutes of Health

Related topics

Related topics

14 relations
Carbohydrate MetabolismCell AdhesionEnzyme GeneFertilization

Broader (2)

Cell Adhesion MoleculesHyaluronidase

Narrower (1)

Spam protein, rat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Characterization of Recombinant Bovine Sperm Hyaluronidase and Identification of an Important Asn-X-Ser/Thr Motif for Its Activity.
Hyaluronidases are a family of enzymes that catalyse the breakdown of hyaluronic acid, which is abundant in the extracellular… 
2016
2016
Effect of cryopreservation on the expression of sperm surface protein PH-20 and the activity of hyaluronidase in human sperm
Review
2015
Review
2015
Is Sperm Hyaluronidase Indispensable in Mammalian Fertilization
Fertilization involves several precisely coordinated steps, including sperm dispersal of the oocyte cumulus mass, adhesion and… 
2014
2014
Characterization of pig sperm hyaluronidase and improvement of the digestibility of cumulus cell mass by recombinant pSPAM1 hyaluronidase in an in vitro fertilization assay.
2012
2012
Tissue-specific gene expression of the fertility-associated proteins ADAM2, CD52, CRISP1, EQ-12, SED1 and Spam1 in the stallion's reproductive tract
2008
2008
Adaptive Evolution of Primate Sperm Proteins
Adaptive pressures throughout primate evolution have shaped sperm and seminal fluid proteins, causing them to change more rapidly… 
2007
2007
Expression of SPAM1 (PH-20) in the Murine Kidney Is Not Accompanied by Hyaluronidase Activity: Evidence for Potential Roles in Fluid and Water Reabsorption
Background:A role for Sperm Adhesion Molecule 1 (SPAM1) hyaluronidase in murine kidney, where Spam1 transcript levels have been… 
2006
2006
Murine Spam1 mRNA: Involvement of AU‐rich elements in the 3′UTR and antisense RNA in its tight post‐transcriptional regulation in spermatids
Sperm adhesion molecule1 (SPAM1), the best characterized hyaluronidase gene, is abundantly expressed in the testis. We attempted… 
2005
2005
Expression of human sperm hyaluronidase PH-20 and its clinical significance in cancer of digestive tract
Objective To investigate the clinical significance of PH-20 mRNA expression on detection of cancer of digestive tract involving… 
1999
1999
Chondrocyte Hyaluronan Hyaluronidase IDENTIFICATION OF CHONDROCYTE HYALURONIDASE ISOZYMES AND REGULATION OF THEIR EXPRESSION BY PRO-INFLAMMATORY CYTOKINES
  • 1999
  • Corpus ID: 180255877
Introduction The load-bearing capacity of articular cartilage is facilitated by the presence of high concentrations of… 
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