Small Ubiquitin-Related Modifier Proteins

Known as: Ubiquitin Related Modifier Protein, Small, Sentrins, Ubiquitin-Related Modifier Protein, Small 
A class of structurally related proteins of 12-20 kDa in size. They covalently modify specific proteins in a manner analogous to UBIQUITIN.
National Institutes of Health

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In BloodProcess of secretionSUMO1 geneagonists
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PIAS1 protein, humanSUMO-1 Protein

Papers overview

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2011
2011
Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB.
Voltage-gated sodium channels (VGSCs) consist of a pore-forming α-subunit and regulatory β-subunits. Several families of… (More)
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2011
2011
Activation of human monocyte-derived dendritic cells in vitro by the biological response modifier arabinoxylan rice bran (MGN-3/Biobran).
Arabinoxylan rice bran (MGN-3/Biobran) is a potent biological response modifier (BRM) that activates natural killer (NK) cells, T… (More)
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Highly Cited
2006
Highly Cited
2006
Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer
Non-specific immunopotentiators, such as polysaccharide K (PSK), also known as OK-432, induce anti-tumor effects via… (More)
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2006
2006
GSTM1 and GSTT1 polymorphisms as modifiers of age at diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) in a homogeneous cohort of individuals carrying a single predisposing mutation.
The variability in phenotype that occurs for so-called 'single-gene disorders' may be because of germline alterations in numerous… (More)
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2003
2003
The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells.
BACKGROUND In experimental models, imidazoquinolines exhibit several immunomodulatory activities via Toll-like receptor signaling… (More)
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Highly Cited
2000
Highly Cited
2000
Adjuvant activities of immune response modifier R-848: comparison with CpG ODN.
R-848 and imiquimod belong to a class of immune response modifiers that are potent inducers of cytokines, including IFN-alpha… (More)
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2000
2000
Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848.
The imidazoquinoline R-848, originally identified as a highly effective antiviral agent, has recently been shown to be capable of… (More)
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2000
2000
Protection of epithelial cells against influenza A virus by a plant derived biological response modifier Ledretan-96.
A multicomponent herbal formula Ledretan-96 was tested on an epithelial tissue culture cell line (MDCK) for its protective… (More)
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1999
1999
Dendritic cell maturation and subsequent enhanced T-cell stimulation induced with the novel synthetic immune response modifier R-848.
Agents that enhance dendritic cell maturation can enhance T-cell activation and therefore may improve the efficiency of vaccines… (More)
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Highly Cited
1997
Highly Cited
1997
Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway
Proteases are now firmly established as major regulators of the "execution" phase of apoptosis. Here, we examine the role of… (More)
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