Smad Proteins, Receptor-Regulated
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Mice overexpressing galectin‐8 [gal‐8 transgenic (Tg)], a secreted mammalian lectin, exhibit enhanced bone turnover and reduced… Expand Members of the transforming growth factor-β (TGF-β) family of secreted proteins are present in all multicellular animals. TGF… Expand Bone morphogenetic proteins (BMPs) induce osteoblastic differentiation in myogenic cells via the phosphorylation of Smads. Two… Expand Little is known about lung carcinoma epidermal growth factor (EGF) kinase pathway signaling within the context of the tissue… Expand Intracellular signaling pathways that converge on Smad 3 are used by both TGF-β and activin A, key cytokines implicated in the… Expand 目的研究射线诱导下Egr-1基因启动子调控腺病毒介导的Smad 7基因在C57BL/6J小鼠Lewis肺癌原发病灶内表达后,对原发灶及远处肺转移发生的影响.方法将Egr-1基因启动子的辐射敏感元件和Smad7 cDNA包装到复制缺陷型腺病毒内,制备成AD… Expand Genetic evidence suggests that the Drosophila ectoderm is patterned by a spatial gradient of bone morphogenetic protein (BMP… Expand Abstract Although Smad 3 is known to serve as a signaling intermediate for the transforming growth factor beta (TGFβ) family in… Expand An emerging theme in transforming growth factor-ss (TGF-ss) signalling is the association of the Smad proteins with diverse… Expand