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Smad Proteins, Inhibitory

Known as: I-Smad Proteins, Inhibitory Smad Proteins, Smad Proteins, Inhibitory [Chemical/Ingredient] 
A sub-family of smad proteins that inhibit cell signaling by RECEPTOR-REGULATED SMAD PROTEINS. They form autoinhibitory feedback loops in the TGF… Expand
National Institutes of Health

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8 relations
In BloodProcess of secretionagonistsantagonists & inhibitors
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Papers overview

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2019
2019
Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer.
Despite the success of approved systemic therapies for estrogen receptor α (ER)-positive breast cancer, drug resistance remains… Expand
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2017
2017
Fibulin-6 regulates pro-fibrotic TGF-β responses in neonatal mouse ventricular cardiac fibroblasts
Fibulin-6, an essential component of extracellular matrix determines the architecture of cellular junctions in tissues undergoing… Expand
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2015
2015
SMAD signaling in the airways of healthy versus asthmatic rhesus macaques highlights a relationship between inflammation and BMPs
Bone Morphogenetic Protein (BMP) signaling is important for correct lung morphogenesis and there is evidence of BMP signaling re… Expand
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2013
2013
ALK2 and BMPR2 knockdown and endothelin-1 production by pulmonary microvascular endothelial cells.
BACKGROUND Many cases of pulmonary arterial hypertension (PAH) are heritable and related to gene mutations in bone morphogenic… Expand
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2010
2010
Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis
BackgroundBone Morphogenetic Protein (BMP)-7 is protective in different animal models of acute and chronic kidney disease. Its… Expand
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Highly Cited
2005
Highly Cited
2005
Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads.
Upon transforming growth factor beta (TGF-beta) stimulation, Smads accumulate in the nucleus, where they regulate gene expression… Expand
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2005
2005
SMAD-Signaltransduktionsmechanismen bei COPD: Verminderung der SMAD6 und -7 mRNA Expression durch Zigarettenrauch
 
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2001
2001
Implication des voies de signalisation des protéines JNK et SMAD dans l'apoptose régulée par le TGF-β1
Le TGF-beta appartient a une famille de mediateurs locaux impliques dans le controle de la proliferation et de la differenciation… Expand
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1999
1999
BMP2シグナル伝達分子 Smad ファミリーによるCbfa-1の発現調節と骨芽細胞への分化誘導との関連
 
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