Sinus Node Dysfunction (disorder)

Known as: Dysfunction, Sinus Node, Sinus Node Disease, Dysfunctions, Sinus Node 
A derangement in the normal functioning of the sinoatrial node. Typically, SA node dysfunction is manifest as sinoatrial exit block or sinus arrest… (More)
National Institutes of Health

Related topics

Related topics

5 relations
CARDIOMYOPATHY, DILATED, 1ESINOATRIAL NODE DYSFUNCTION AND DEAFNESSSick Sinus SyndromeSinus bradycardia

Broader (1)

Conduction disorder of the heart

Papers overview

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Highly Cited
2011
Highly Cited
2011
Oxidized CaMKII causes cardiac sinus node dysfunction in mice.
Sinus node dysfunction (SND) is a major public health problem that is associated with sudden cardiac death and requires surgical… (More)
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Highly Cited
2008
Highly Cited
2008
Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease.
The identification of nearly a dozen ion channel genes involved in the genesis of human atrial and ventricular arrhythmias has… (More)
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Highly Cited
2007
Highly Cited
2007
Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists.
AIMS Significant brady- and tachyarrhythmias may occur in active endurance athletes. It is controversial whether these… (More)
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Highly Cited
2004
Highly Cited
2004
Electrophysiological and electroanatomic characterization of the atria in sinus node disease: evidence of diffuse atrial remodeling.
BACKGROUND The normal sinus pacemaker complex is an extensive structure within the right atrium. We hypothesized that patients… (More)
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Highly Cited
2004
Highly Cited
2004
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression.
BACKGROUND Homozygous mutant mice with a defect of klotho gene expression (kl/kl) show multiple age-related disorders and… (More)
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Highly Cited
2003
Highly Cited
2003
Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction.
BACKGROUND Dual-chamber (DDDR) pacing preserves AV synchrony and may reduce heart failure (HF) and atrial fibrillation (AF… (More)
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Highly Cited
2003
Highly Cited
2003
Pacemaker channel dysfunction in a patient with sinus node disease.
The cardiac pacemaker current I(f) is a major determinant of diastolic depolarization in sinus nodal cells and has a key role in… (More)
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Highly Cited
2003
Highly Cited
2003
Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A).
Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to sinus node dysfunction and diagnosed by… (More)
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Highly Cited
2002
Highly Cited
2002
Ventricular pacing or dual-chamber pacing for sinus-node dysfunction.
BACKGROUND Dual-chamber (atrioventricular) and single-chamber (ventricular) pacing are alternative treatment approaches for sinus… (More)
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Highly Cited
2000
Highly Cited
2000
Congenital Deafness and Sinoatrial Node Dysfunction in Mice Lacking Class D L-Type Ca2+ Channels
Voltage-gated L-type Ca2+ channels (LTCCs) containing a pore-forming alpha1D subunit (D-LTCCs) are expressed in neurons and… (More)
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