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Signal Transduction Inhibitor

A substance that blocks signals passed from one molecule to another inside a cell. Blocking these signals can affect many functions of the cell… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
TAK-242 Protects Against Apoptosis in Coronary Microembolization-Induced Myocardial Injury in Rats by Suppressing TLR4/NF-κB Signaling Pathway
Background/Aims: Myocardial apoptosis is heavily implicated in the myocardial injury caused by coronary microembolization (CME… 
2011
2011
Tgf-β signal transduction inhibitor
A compound represented by formula (I) or a pharmacologically acceptable salt thereof; and use of the compound or the… 
2011
2011
Effect of Donor JNK Signal Transduction Inhibition on Transplant Outcome in Brain Dead Rat Model
Renal grafts from brain-dead donors compared to living donors have a significantly shortened survival time due to heightened… 
2010
2010
Efficacy and safety of RAD001 in advanced biliary tract cancer (BTC) patients (pts) progressing after first-line chemotherapy: A phase II study.
e14500 Background: RAD001 (everolimus) is a derivate of rapamycin which acts as a signal transduction inhibitor. Its target is… 
2009
2009
The novel selective Toll-like receptor 4 signal transduction inhibitor TAK-242 prevents endotoxaemia in conscious guinea-pigs
2008
2008
Molekular getriggerte Therapie des hormonrefraktären Prostatakarzinoms
ZusammenfassungMolekular getriggerte Therapien, sog. „targeted therapies“ haben bereits bei einigen Tumorentitäten die… 
2008
2008
[Feasibility of targeted therapy based on immunohistochemical expression analysis in androgen-independent prostate cancer].
Targeted therapies present an interesting treatment option in prostate cancer. The aim of our study was to analyze the expression… 
Review
2004
Review
2004
Inhibition of HER1 signaling pathway enhances antitumor effect of endocrine therapy in breast cancer
Epidermal growth factor receptor (EGFR)/HER1 is expressed at high levels in at least 20% of breast cancers. This high expression… 
2001
2001
Carboxyamido-Triazole (CAI)-a Novel “static” Signal Transduction Inhibitor Induces Apoptosis in Human B-Cell Chronic Lymphocytic Leukemia Cells
Signal transduction is a key mechanism by which both proliferative and apoptotic processes of B-cell chronic lymphocytic leukemia… 
2000
2000
Product comprising a signal transduction inhibitor of heterotrimeric g proteins in combination with other cytostatic agent for therapeutic use in the treatment of cancer
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