FAQ

Sertoli cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1953-2018
051019532017

Related topics

Related topics

2 relations

Narrower (1)

Sertoli cell development

Broader (1)

male gonad development

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Sertoli cell differentiation
male gonad development
Sertoli cell development

Papers overview

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2009
2009
The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation.
Activation by the Y-encoded testis determining factor SRY and maintenance of expression of the Sox9 gene encoding the central… (More)
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Highly Cited
2008
Highly Cited
2008
Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer.
The mammalian Y chromosome acts as a dominant male determinant as a result of the action of a single gene, Sry, whose role in sex… (More)
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Highly Cited
2005
Highly Cited
2005
Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination.
We have raised an antibody specifically recognizing endogenous mouse SRY protein and used it to investigate the molecular and… (More)
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Highly Cited
2004
Highly Cited
2004
Functional analysis of Sox8 and Sox9 during sex determination in the mouse.
Sex determination in mammals directs an initially bipotential gonad to differentiate into either a testis or an ovary. This… (More)
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Highly Cited
2002
Highly Cited
2002
Sexually dimorphic development of mouse primordial germ cells: switching from oogenesis to spermatogenesis.
During embryogenesis, primordial germ cells (PGCs) have the potential to enter either spermatogenesis or oogenesis. In a female… (More)
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Highly Cited
2000
Highly Cited
2000
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes.
The functions of estrogen receptors (ERs) in mouse ovary and genital tracts were investigated by generating null mutants for… (More)
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Highly Cited
1999
Highly Cited
1999
Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad.
In mammals a single gene on the Y chromosome, Sry, controls testis formation. One of the earliest effects of Sry expression is… (More)
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Highly Cited
1996
Highly Cited
1996
Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
Heterozygous mutations in SOX9 lead to a human dwarfism syndrome, Campomelic dysplasia. Consistent with a role in sex… (More)
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Highly Cited
1995
Highly Cited
1995
Expression of Sry, the mouse sex determining gene.
In the mouse, Sry is expressed by germ cells in the adult testis and by somatic cells in the genital ridge. Transcripts in the… (More)
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Highly Cited
1985
Highly Cited
1985
Extracellular matrix regulates Sertoli cell differentiation, testicular cord formation, and germ cell development in vitro
Sertoli cell preparations isolated from 10-day-old rats were cultured on three different substrates: plastic, a matrix deposited… (More)
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