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Secretory Component

Known as: Secretory Component [Chemical/Ingredient], Secretory Piece 
The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions… 
National Institutes of Health

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Related topics

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Broader (1)

Immunologic Factors
In BloodPolymeric Immunoglobulin Receptorsaspects of radiation effectsphysiological aspects

Papers overview

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1999
1999
Mapping the Interaction Between Murine IgA and Murine Secretory Component Carrying Epitope Substitutions Reveals a Role of Domains II and III in Covalent Binding to IgA*
We have identified sites for epitope insertion in the murine secretory component (SC) by replacing individual surface-exposed… 
1987
1987
Uncoupling of the secretory pathways for IgA and secretory component by cholestasis.
Circulating polymeric immunoglobulin A (IgA) binds to secretory component (SC) on the surface of rat hepatocytes and is… 
1986
1986
The importance of the Fc receptors for IgA in the recognition of IgA by mouse liver cells: its comparison with carbohydrate and secretory component receptors.
The numbers of murine hepatocytes and Kupffer cells with receptors for human polymeric (pIgA) or monomeric IgA (mIgA) were… 
1985
1985
Differences in fragmentation between bound and unbound bovine secretory component suggest a model for its interaction with polymeric immunoglobulin.
Unbound bovine secretory component was cleaved into two-domain and one-domain fragments by trypsin within 1 h. Bovine secretory… 
1983
1983
The occurrence of secretory IgM in the bile of rats.
The concentration of IgM in the bile of normal rats is extremely small, too low to be detected by conventional immunodiffusion… 
1978
1978
A comparison of secretory component - immunoglobulin interactions amongst different species.
1) SC from many species may be isolated by affinity chromatography to human IgA-Sepharose. 2) In some species SC may exist in two… 
1976
1976
Synthesis of immunoglobulin and secretory component by gastrointestinal mucosa in patients with hypogammaglobulinaemia or IgA deficiency.
Biopsies of intestinal mucosa from patients with adult hypogammaglobulinaemia or selective IgA deficiency have been studied for… 
Highly Cited
1975
Highly Cited
1975
IgA and IgA diphtheria antitoxin responses from human tonsil lymphocytes.
Human tonsil lymphocytes were stimulated with diphtheria toxoid and then cultured in a Marbrook culture system so that antibodies… 
1971
1971
Immunoglobulin classes in aquatic mammals. Characterization by serologic cross-reactivity, molecular size and binding of human free secretory component.
On the basis of serologic cross-reactivity, three immunoglobulin classes homologous to human IgG, IgM and IgA were identified in… 
1970
1970
Secretory Piece linked to IgM in Individuals deficient in IgA
THE IgA in exocrine secretions, by contrast with that in serum, is an 11S dimer containing an additional antigenic fragment…