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Schwann cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2018
051019792018

Related topics

Related topics

3 relations

Narrower (1)

Schwann cell development

Broader (1)

peripheral nervous system development
regulation of Schwann cell differentiation

Related mentions per year

Related mentions per year

1979-2018
197019801990200020102020
Schwann cell differentiation
Schwann cell development
peripheral nervous system development
regulation of Schwann cell differentiation

Papers overview

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Highly Cited
2009
Highly Cited
2009
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity
Notch signaling is central to vertebrate development, and analysis of Notch has provided important insights into pathogenetic… (More)
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Highly Cited
2009
Highly Cited
2009
Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.
Schwann cells develop from multipotent neural crest cells and form myelin sheaths around axons that allow rapid transmission of… (More)
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Highly Cited
2006
Highly Cited
2006
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Malignant peripheral nerve sheath tumors (MPNST) are highly invasive soft tissue sarcomas that arise within the peripheral nerve… (More)
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Highly Cited
2005
Highly Cited
2005
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.
Egr2 is a transcription factor required for peripheral nerve myelination in rodents, and mutations in Egr2 are associated with… (More)
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Highly Cited
2004
Highly Cited
2004
Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination.
Schwann cells are the myelinating glia of the peripheral nervous system, and their development is regulated by various growth… (More)
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Highly Cited
2003
Highly Cited
2003
Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve.
Laminins are heterotrimeric extracellular matrix proteins that regulate cell viability and function. Laminin-2, composed of… (More)
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Highly Cited
2000
Highly Cited
2000
Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity.
In this report, we have investigated the signaling pathways that are activated by, and mediate the effects of, the neuregulins… (More)
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Highly Cited
1996
Highly Cited
1996
The POU factor Oct-6 and Schwann cell differentiation.
The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in… (More)
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Highly Cited
1996
Highly Cited
1996
The transcription factors SCIP and Krox-20 mark distinct stages and cell fates in Schwann cell differentiation.
We have studied the transcription factors SCIP and Krox-20 in differentiating Schwann cells-during normal development, in… (More)
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Highly Cited
1991
Highly Cited
1991
The effects of cAMP on differentiation of cultured Schwann cells: progression from an early phenotype (04+) to a myelin phenotype (P0+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition
The present experiments were designed to clarify the relationship between cAMP elevation, proliferation and differentiation in… (More)
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