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Saralasin

Known as: Angiotensin II, Sarcosyl(1)-Alanine(8)-, 1 Sar 8 Ala Angiotensin II, Sar-Arg-Val-Tyr-Val-His-Pro-Ala 
An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (4)

Angiotensin II Type 1 Receptor BlockersAngiotensinsAntihypertensive Agentspeptide analog
In BloodProcess of secretionSaralasin Acetateagonists

Papers overview

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Highly Cited
1986
Highly Cited
1986
Angiotensin peptides stimulate phosphoinositide breakdown and prolactin release in anterior pituitary cells in culture.
We investigated the effects of angiotensin peptides on the breakdown of specific membrane phospholipids, the inositol lipids, in… 
1983
1983
Vasopressin release induced by water deprivation: effects of centrally administered saralasin.
Uncertainty exists as to whether endogenous angiotensin activates brain mechanisms controlling vasopressin (AVP) secretion during… 
1981
1981
Control of Rat Renal Vascular Resistance during Alterations in Sodium Balance
Renal perfusion pressure (RPP), total renal blood flow (RBF), and renal vascular resistance (RVR) were comparable in groups of… 
1980
1980
Effect of saralasin and indomethacin on renal function in developing piglets.
To investigate the influence of angiotensin II (AII) and renal prostaglandins on neonatal renal hemodynamics and sodium excretion… 
Highly Cited
1980
Highly Cited
1980
The Antihypertensive Effect of Captopril
SUMMARY The acute effect of the orally-active converting enzyme inhibitor, captopril, was compared to that of saralasin in 13… 
1979
1979
The Immediate Pressor Response to Saralasin in Man: A Test of Angiotensin II Receptor Vacancy
Saralasin, 10 μg/kg per min, caused an immediate rise in blood pressure in 52 of 57(91.2%) hypertensive patients. The increase in… 
1978
1978
Hemodynamic Correlates of Saralasin‐induced Arterial Pressure Changes
Angiotensin antagonists have proved useful in elucidating the clinical role of the renin-angiotensin system; and their diagnostic… 
1977
1977
Diuretic therapy and response of essential hypertension to saralasin.
Thirty-four patients, most with a low-renin "essential" hypertension, and seven normal subjects were placed on diuretic therapy… 
1977
1977
Blockade of renin or angiotensin for understanding human hypertension: a comparison of propranolol, saralasin and converting enzyme blockade.
To understand the role of the renin-angiotensin-aldosterone system in the pathogenesis of human hypertension, in serial studies… 
1975
1975
Role of angiotensin II in experimental renal hypertension in the rabbit.
Hypertension was produced in rabbits by constricting the left renal artery; in nine rabbits the opposite kidney was removed and…