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STX 140

Known as: STX-140, STX140 
National Institutes of Health

Papers overview

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2015
2015
Tumor neo-angiogenesis is regulated, in part, by the hypoxia-inducible gene HIF1. Evidence suggests HIF1 associates with… 
2013
2013
Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor… 
Highly Cited
2010
Highly Cited
2010
Background:Class III β-tubulin overexpression is a marker of resistance to microtubule disruptors in vitro, in vivo and in the… 
2009
2009
Many anticancer drugs target microtubules and induce apoptosis. However, improved microtubule-targeting drugs, such as STX140 and… 
2009
2009
The anti-proliferative and anti-angiogenic properties of the endogenous oestrogen metabolite, 2-methoxyoestradiol (2-MeOE2), are… 
Highly Cited
2008
Highly Cited
2008
Purpose: The aim of these studies was to characterize the action of STX140 in a P-glycoprotein–overexpressing tumor cell line… 
2008
2008
Drug combination therapy is a key strategy to improve treatment efficacy and survival of cancer patients. In this study the… 
2008
2008
UNLABELLED There is a continued need for orally bioavailable anticancer compounds that exhibit good efficacy against breast… 
2008
2008
Purpose:The aimof these studieswas to characterize the actionof STX140 in a P-glycoprotein ^ overexpressing tumor cell line both… 
2007
2007
Therapies for hormone-independent prostate and breast cancer are limited, with the effectiveness of the taxanes compromised by…